{"created":"2021-03-01T06:19:14.545008+00:00","id":12294,"links":{},"metadata":{"_buckets":{"deposit":"b9e7a3b2-bc9c-4621-a98f-e0e81a1386e4"},"_deposit":{"created_by":17,"id":"12294","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"12294"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00012294","sets":["499:508:509:1277"]},"author_link":["38858","38859","38860","38861"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"144","bibliographicPageStart":"139","bibliographicVolumeNumber":"72","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We previously reported that the disruption of cell spreading by v-Crk was dependent on the activation of the MEK/ERK pathway. Here we demonstrate that the activation of that pathway is sufficient to suppress cell spreading. The MEK/ERK pathway regulates the activity of various proteins including AP-1, which is a transcriptional factor composed of heterodimeric proteins. To examine whether AP-1 activity is required for the suppression of cell spreading by the activation of the MEK/ERK pathway, we expressed BATF, which is a negative regulator of AP-1. The expression of BATF clearly restored cell spreading that was suppressed by the activation of MEK/ERK pathway. In addition, a disrupted formation of stress fibers and focal adhesions by such activation was restored by the suppression of AP-1. Our results define an essential role of the MEK/ERK/AP-1 pathway in the disruption of actin cytoskeleton and cell spreading.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/14175"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.72.3-4.139","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Xu, Feng","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"38858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Satoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"38859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hamaguchi, Michinari","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"38860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Senga, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"38861","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"p139-144_Xu.pdf","filesize":[{"value":"443.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"p139-144_Xu.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/12294/files/p139-144_Xu.pdf"},"version_id":"a5934acc-ed40-4a01-9fe4-c69de7a339e6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"MEK","subitem_subject_scheme":"Other"},{"subitem_subject":"ERK","subitem_subject_scheme":"Other"},{"subitem_subject":"AP-1","subitem_subject_scheme":"Other"},{"subitem_subject":"BATF","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell spreading","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Disruption of Cell Spreading by the Activation of MEK/ERK Pathway is Dependent on AP-1 Activity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Disruption of Cell Spreading by the Activation of MEK/ERK Pathway is Dependent on AP-1 Activity","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1277"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-09-21"},"publish_date":"2010-09-21","publish_status":"0","recid":"12294","relation_version_is_last":true,"title":["Disruption of Cell Spreading by the Activation of MEK/ERK Pathway is Dependent on AP-1 Activity"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:36:01.876870+00:00"}