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A possible role of NF-κB and HSP72 in skeletal muscle hypertrophy induced by heat stress
http://hdl.handle.net/2237/14840
a9874366-56a0-4ca4-85a7-084e9d5f5c2c
名前 / ファイル | ライセンス | アクション | |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2011-05-20 | |||||
タイトル | ||||||
タイトル | A possible role of NF-κB and HSP72 in skeletal muscle hypertrophy induced by heat stress | |||||
その他のタイトル | ||||||
その他のタイトル | 温熱ストレスによる骨格筋肥大における NF-κBとHSP72 の役割 | |||||
著者 |
大野, 善隆
× 大野, 善隆 |
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抄録 | ||||||
内容記述 | Effects of heat stress on phosphorylated nuclear factor-κB (phospho-NF-κB) and tumor necrosis factor α (TNFα) contents in skeletal muscles were studied. Male Wistar rats (7-week-old) were randomly assigned to control and heat-stressed groups. Rats in heat-stressed group were exposed to heat stress (42°C for 60 min) in an incubator without anesthesia. Soleus muscles were dissected and weighted 1, 3, and 7 days after the heat exposure. Significant increases in the wet weight and protein content of soleus were observed 7 days following the exposure (p < 0.05). Heat stress also induced the up-regulation of heat shock protein 72 (HSP72), IκBα (inhibitor of NF-κB) and the increase in the relative population of Pax7-positive satellite cells to total muscle nuclei before the increase in muscle mass. The content levels of phospho-NF-κB and TNFα were significantly decreased 1 and 3 days after heat stress, respectively (p < 0.05). A negative correlation between HSP72 and phospho-NF-κB contents was observed 1 day after the heat exposure. These observations suggest that the decrease in NF-κB signaling may play a part of a role in heat stress-associated muscle hypertrophy. | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 名古屋大学博士学位論文 学位の種類:博士(リハビリテーション療法学) (課程) 学位授与年月日:平成23年3月25日 | |||||
内容記述タイプ | Other | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
書誌情報 | 発行日 2011-03-25 | |||||
学位授与年度 | ||||||
学位授与年度 | 2010 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2011-03-25 | |||||
学位授与番号 | ||||||
学位授与番号 | 13901甲第9070号 | |||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/14840 | |||||
識別子タイプ | HDL |