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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医保博・論医保博)

A possible role of NF-κB and HSP72 in skeletal muscle hypertrophy induced by heat stress

http://hdl.handle.net/2237/14840
a9874366-56a0-4ca4-85a7-084e9d5f5c2c
名前 / ファイル ライセンス アクション
k9070.pdf k9070.pdf (287.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2011-05-20
タイトル
タイトル A possible role of NF-κB and HSP72 in skeletal muscle hypertrophy induced by heat stress
その他のタイトル
その他のタイトル 温熱ストレスによる骨格筋肥大における NF-κBとHSP72 の役割
著者 大野, 善隆

× 大野, 善隆

WEKO 40804

大野, 善隆

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抄録
内容記述 Effects of heat stress on phosphorylated nuclear factor-κB (phospho-NF-κB) and tumor necrosis factor α (TNFα) contents in skeletal muscles were studied. Male Wistar rats (7-week-old) were randomly assigned to control and heat-stressed groups. Rats in heat-stressed group were exposed to heat stress (42°C for 60 min) in an incubator without anesthesia. Soleus muscles were dissected and weighted 1, 3, and 7 days after the heat exposure. Significant increases in the wet weight and protein content of soleus were observed 7 days following the exposure (p < 0.05). Heat stress also induced the up-regulation of heat shock protein 72 (HSP72), IκBα (inhibitor of NF-κB) and the increase in the relative population of Pax7-positive satellite cells to total muscle nuclei before the increase in muscle mass. The content levels of phospho-NF-κB and TNFα were significantly decreased 1 and 3 days after heat stress, respectively (p < 0.05). A negative correlation between HSP72 and phospho-NF-κB contents was observed 1 day after the heat exposure. These observations suggest that the decrease in NF-κB signaling may play a part of a role in heat stress-associated muscle hypertrophy.
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類:博士(リハビリテーション療法学) (課程) 学位授与年月日:平成23年3月25日
内容記述タイプ Other
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
書誌情報 発行日 2011-03-25
学位授与年度
学位授与年度 2010
学位授与年月日
学位授与年月日 2011-03-25
学位授与番号
学位授与番号 13901甲第9070号
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/14840
識別子タイプ HDL
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