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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 73(1-2)

REGULATION OF STRESS-ACTIVATED MAP KINASE PATHWAYS DURING CELL FATE DECISIONS

https://doi.org/10.18999/nagjms.73.1-2.1
013668a2-f80d-4870-a498-a65fb978a783
名前 / ファイル ライセンス アクション
v73n12p1_14.pdf v73n12p1_14.pdf (854.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2011-06-01
タイトル
タイトル REGULATION OF STRESS-ACTIVATED MAP KINASE PATHWAYS DURING CELL FATE DECISIONS
著者 TAKEKAWA, MUTSUHIRO

× TAKEKAWA, MUTSUHIRO

WEKO 40896

TAKEKAWA, MUTSUHIRO

Search repository
KUBOTA, YUJI

× KUBOTA, YUJI

WEKO 40897

KUBOTA, YUJI

Search repository
NAKAMURA, TAKANORI

× NAKAMURA, TAKANORI

WEKO 40898

NAKAMURA, TAKANORI

Search repository
ICHIKAWA, KENJI

× ICHIKAWA, KENJI

WEKO 40899

ICHIKAWA, KENJI

Search repository
キーワード
主題Scheme Other
主題 SAPK
キーワード
主題Scheme Other
主題 GADD45
キーワード
主題Scheme Other
主題 MTK1
キーワード
主題Scheme Other
主題 Docking interaction
キーワード
主題Scheme Other
主題 Stress granules
抄録
内容記述 Mammalian cells are frequently exposed to a variety of environmental stresses, such as ultraviolet rays, ionizing radiation, genotoxins, heat shock, and oxidative stress. In coping with the barrage of these and other stresses, multi-cellular eukaryotic organisms have developed a strategy as to how damaged cells will respond to stresses. In general, if the intensity of the damage is moderate, the cell will seek to repair the damage. If, however, the damage to a cell is too severe to be repaired, the affected cells are eliminated by apoptosis. This cell death reduces the risk to the organism as a whole, such as development of a cancer. Such a crucial decision between survival and death is, at least in part, mediated by the stress-activated MAP kinase (SAPK) pathways. SAPKs are a group of serine/threonine protein kinases that convert extracellular stress stimuli into diverse cellular responses, including cell cycle arrest, apoptotic cell death, and cytokine production, through phosphorylation of specific target proteins. Recent progress in the identification of molecules that participate in the SAPK pathways, such as GADD45 proteins and Wip1, has provided new insights, not only into the molecular basis of the cellular response to environmental stress, but also into the etiology of human diseases including cancer.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.73.1-2.1
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 73, 号 1-2, p. 1-14, 発行日 2011-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7312/7312.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/14910
識別子タイプ HDL
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