@phdthesis{oai:nagoya.repo.nii.ac.jp:00013027,
 author = {Muramatsu, Takashi and Yatsuya, Hiroshi and Toyoshima, Hideaki and Sasaki, Satoshi and Li, Yuanying and Otsuka, Rei and Wada, Keiko and Hotta, Yo and Mitsuhashi, Hirotsugu and Matsushita, Kunihiro and Murohara, Toyoaki and Tamakoshi, Koji},
 month = {Mar},
 note = {Objective: To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA+DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake. Method: We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA+DHA intake as the reference were calculated by logistic regression analysis. Results: Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA +DHA were 47.9 years, 22.9 kg/m^2, and 1.90 g/day (0.88 %E) and 0.77 g/day (0.36 %E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1 = 0.74, P for trend = 0.01) and the association was observed only in subjects with a BMI < 25 kg/m^2 (P for interaction = 0.033). However EPA+DHA showed no such associations consistently. Conclusion: Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women., 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成23年3月25日 村松崇氏の博士論文として提出された},
 school = {名古屋大学, NAGOYA University},
 title = {Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese.},
 year = {2010}
}