{"created":"2021-03-01T06:20:01.616497+00:00","id":13028,"links":{},"metadata":{"_buckets":{"deposit":"86e6b5ae-a217-4328-9cfc-82c6f8f4f413"},"_deposit":{"id":"13028","owners":[],"pid":{"revision_id":0,"type":"depid","value":"13028"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00013028","sets":["499:960:1165"]},"author_link":["40966","40967","40968","40969","40970","40971","40972","40973","40974","40975","40976","40977","40978","40979"],"item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"665","bibliographicPageStart":"660","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Carcinogenesis","bibliographic_titleLang":"en"}]}]},"item_12_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2010-04-01"}]},"item_12_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"名古屋大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"NAGOYA University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13901","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The main lifestyle contributor to acetaldehyde exposure is the drinking of alcoholic beverages, but tobacco smoke also makes some contribution. Although acetaldehyde is associated with upper aerodigestive tract cancer risk, in accordance with genetically determined acetaldehyde metabolism, it is unclear whether lung cancer, a representative smoking-related cancer, is associated with acetaldehyde or genes impacting its metabolism. We conducted a case–control study to examine possible interaction between smoking and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism (rs671) on the risk of lung cancer in Japanese. Subjects were 718 lung cancer cases and 1416 noncancer controls enrolled in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center. Lifestyle factors, including smoking, were determined by self-administered questionnaire. We applied pack-years (PY; categorized into five levels: never, <15, <30, <45 and ≥45) as a marker of cumulative exposure to smoking. The impact of smoking, ALDH2 genotype, and their interaction on lung cancer risk were assessed by odds ratio (OR) and 95% confidence interval adjusted for potential confounders. Adjusted ORs for PY <15, <30, <45 and ≥45 relative to never smokers among those with Glu/Glu or Glu/Lys were 1.39, 1.80, 3.44 and 6.25, respectively (P-trend ＝ 1.4 × 10^-30). In contrast, ORs among Lys/Lys were 1.01, 10.2, 11.4 and 23.2, respectively (P-trend ＝ 2.6 × 10^-7). Interaction between ALDH2 genotype (Glu/Glu ＋ Glu/Lys versus Lys/Lys) and cumulative smoking dose was statistically significant (P ＝ 0.036) and was consistently observed in the analysis among never-drinkers (interaction P ＝ 0.041). These results suggest that ALDH2 Lys/Lys, a null enzyme activity genotype, modifies the impact of smoking on the risk of lung cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_12_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成23年3月25日 朴智栄氏の博士論文として提出された","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_12_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第9058号"}]},"item_12_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://dx.doi.org/10.1093/carcin/bgq021"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/14923"}]},"item_12_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_12_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/carcin/bgq021","subitem_relation_type_select":"DOI"}}]},"item_12_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author 2010. Published by Oxford University Press.","subitem_rights_language":"en"}]},"item_12_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_12_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1460-2180","subitem_source_identifier_type":"EISSN"}]},"item_12_text_63":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_text_value":"2010"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Park, Ji Young","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuo, Keitaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hidemi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hosono, Satoyo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawase, Takakazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Miki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oze, Isao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hida, Toyoaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yatabe, Yasushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mitsudomi, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takezaki, Toshiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tajima, Kazuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Hideo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40979","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"k9058.pdf","filesize":[{"value":"80.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"k9058.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/13028/files/k9058.pdf"},"version_id":"4d99d2fa-7cf9-446c-9877-edad279d4c18"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population","subitem_title_language":"en"}]},"item_type_id":"12","owner":"1","path":["1165"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-06-07"},"publish_date":"2011-06-07","publish_status":"0","recid":"13028","relation_version_is_last":true,"title":["Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T03:59:59.949710+00:00"}