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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 73(3-4)

Spatial and temporal distribution of growth factors receptors in the callus: Implications for improvement of distraction osteogenesis

https://doi.org/10.18999/nagjms.73.3-4.117
https://doi.org/10.18999/nagjms.73.3-4.117
e4c6209a-bbb9-45c8-b1d4-3c74ab3cc0a0
名前 / ファイル ライセンス アクション
v73n34p117_127.pdf v73n34p117_127.pdf (896.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2011-08-24
タイトル
タイトル Spatial and temporal distribution of growth factors receptors in the callus: Implications for improvement of distraction osteogenesis
著者 Siwicka, Karolina A

× Siwicka, Karolina A

WEKO 42175

Siwicka, Karolina A

Search repository
Kitoh, Hiroshi

× Kitoh, Hiroshi

WEKO 42176

Kitoh, Hiroshi

Search repository
Kawasumi, Motoaki

× Kawasumi, Motoaki

WEKO 42177

Kawasumi, Motoaki

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 42178

Ishiguro, Naoki

Search repository
キーワード
主題Scheme Other
主題 Distraction osteogenesis
キーワード
主題Scheme Other
主題 Growth factors
キーワード
主題Scheme Other
主題 Flt-1
キーワード
主題Scheme Other
主題 TGFbR1
キーワード
主題Scheme Other
主題 IGF-1R
キーワード
主題Scheme Other
主題 PDGFRα
抄録
内容記述 Management of bone deficits by distraction osteogenesis is an appreciated but lengthy procedure. To accelerate the consolidation of newly formed distraction callus, an administration of growth factors into the distraction gap has been suggested. Changes in expression of growth factors receptors in the distracted callus during consolidation were studied in order to improve our understanding of the underlying molecular mechanisms and to provide a scientific basis for clinical application of growth factors. In a model of rat bone lengthening the expression of receptors for: vascular endothelial growth factor, transforming growth factor b1, insulin like growth factor and platelet derived growth factor were evaluated semiquantitatively with immunohistochemistry and quantitatively with real time PCR in various callus zones at zero, one and two weeks of consolidation. Overall growth factors receptors’ expression was highest at the beginning of consolidation. It was strongest in the trabecular bone and weakest in the fibrous zone. Transforming growth factor b receptor 1 was most abundant and vascular endothelial growth factor receptor 1, although scarce, showed the most consistent expression. In contrast to the osteogenic zones, the fibrous zone demonstrated a dramatic loss of the growth factors receptors over time. High growth factors receptors expression shortly after termination of the distraction may warrant the maximal callus’ response to injected growth factors. Rapid decline of growth factors receptors in the fibrous zone may imply its decreasing sensitivity to growth factors and, as a consequence, a declining osteogenic potential.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.73.3-4.117
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 73, 号 3-4, p. 117-127, 発行日 2011-08
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7334/7334.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/15354
識別子タイプ HDL
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