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Spatial and temporal distribution of growth factors receptors in the callus: Implications for improvement of distraction osteogenesis
https://doi.org/10.18999/nagjms.73.3-4.117
https://doi.org/10.18999/nagjms.73.3-4.117e4c6209a-bbb9-45c8-b1d4-3c74ab3cc0a0
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2011-08-24 | |||||
タイトル | ||||||
タイトル | Spatial and temporal distribution of growth factors receptors in the callus: Implications for improvement of distraction osteogenesis | |||||
著者 |
Siwicka, Karolina A
× Siwicka, Karolina A× Kitoh, Hiroshi× Kawasumi, Motoaki× Ishiguro, Naoki |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | Distraction osteogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Growth factors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Flt-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TGFbR1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IGF-1R | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PDGFRα | |||||
抄録 | ||||||
内容記述 | Management of bone deficits by distraction osteogenesis is an appreciated but lengthy procedure. To accelerate the consolidation of newly formed distraction callus, an administration of growth factors into the distraction gap has been suggested. Changes in expression of growth factors receptors in the distracted callus during consolidation were studied in order to improve our understanding of the underlying molecular mechanisms and to provide a scientific basis for clinical application of growth factors. In a model of rat bone lengthening the expression of receptors for: vascular endothelial growth factor, transforming growth factor b1, insulin like growth factor and platelet derived growth factor were evaluated semiquantitatively with immunohistochemistry and quantitatively with real time PCR in various callus zones at zero, one and two weeks of consolidation. Overall growth factors receptors’ expression was highest at the beginning of consolidation. It was strongest in the trabecular bone and weakest in the fibrous zone. Transforming growth factor b receptor 1 was most abundant and vascular endothelial growth factor receptor 1, although scarce, showed the most consistent expression. In contrast to the osteogenic zones, the fibrous zone demonstrated a dramatic loss of the growth factors receptors over time. High growth factors receptors expression shortly after termination of the distraction may warrant the maximal callus’ response to injected growth factors. Rapid decline of growth factors receptors in the fibrous zone may imply its decreasing sensitivity to growth factors and, as a consequence, a declining osteogenic potential. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.73.3-4.117 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-7622 | |||||
書誌情報 |
Nagoya Journal of Medical Science 巻 73, 号 3-4, p. 117-127, 発行日 2011-08 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7334/7334.html | |||||
識別子タイプ | URI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/15354 | |||||
識別子タイプ | HDL |