{"created":"2021-03-01T06:20:29.627945+00:00","id":13464,"links":{},"metadata":{"_buckets":{"deposit":"225caa44-9d3e-42c7-ad49-0684d3edb535"},"_deposit":{"created_by":17,"id":"13464","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"13464"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00013464","sets":["499:508:509:1359"]},"author_link":["42257","42258","42259","42260","42261","42262","42263"],"control_number":"13464","item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"209","bibliographicPageStart":"205","bibliographicVolumeNumber":"73","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A 58-year-old woman was referred to our hospital because of liver dysfunction. Her serum levels of AST (619 IU/l) and ALT (603 IU/l) had increased. Histological findings in the liver biopsy were compatible to autoimmune hepatitis (AIH), and the diagnosis of AIH was confirmed by the diagnostic criteria. She was admitted to a nearby hospital 3 years ago, and diagnosed with Graves’ disease. She received methimazole (MMI) at first, which was discontinued due to liver injury in one month, then propylthiouracil (PTU) was administered. One year later, transaminase increased and was decreased by stopping PTU administration. PTU was restarted after her transaminase decreased, but a recurrence of hepatotoxicity was observed, and she was referred to our hospital. Oral prednisolone decreased liver function immediately. In this case, PTU-induced liver injury was suspected as a possible trigger of AIH. While PTU remains a commonly used drug in the treatment of hyperthyroidism, severe liver injury is reported in some cases. If liver injury is observed in patients treated with PTU, rechallenge is not recommended in order to avoid severe hepatotoxicity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/15363"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.73.3-4.205","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SATO, IKUKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"42257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TSUNEKAWA, TAKU","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"42258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHINOHARA, YURI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"42259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NISHIO, YUICHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"42260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHIMIZU, YUKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"42261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SUZUKI, YASUHIKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"42262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YOSHIOKA, SHUKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"42263","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"v73n34p205_209.pdf","filesize":[{"value":"356.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v73n34p205_209.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/13464/files/v73n34p205_209.pdf"},"version_id":"2e7c33eb-da51-4876-9bec-dfdde8e164fb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Graves’ disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Propylthiouracil","subitem_subject_scheme":"Other"},{"subitem_subject":"Autoimmune hepatitis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A CASE OF AUTOIMMUNE HEPATITIS WITH GRAVES’ DISEASE TREATED BY PROPYLTHIOURACIL","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A CASE OF AUTOIMMUNE HEPATITIS WITH GRAVES’ DISEASE TREATED BY PROPYLTHIOURACIL","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1359"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-08-25"},"publish_date":"2011-08-25","publish_status":"0","recid":"13464","relation_version_is_last":true,"title":["A CASE OF AUTOIMMUNE HEPATITIS WITH GRAVES’ DISEASE TREATED BY PROPYLTHIOURACIL"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:46:02.503895+00:00"}