{"_buckets": {"deposit": "6c77c651-de51-45f6-9e39-9ac9e7c0710b"}, "_deposit": {"id": "1357", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1357"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00001357", "sets": []}, "author_link": ["3052", "3053", "3054", "3055", "3056", "3057", "3058", "3059", "3060"], "item_10_alternative_title_19": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Loss of Ca2+ sensitization in b-adrenergic action", "subitem_alternative_title_language": "en"}]}, "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "191", "bibliographicPageStart": "183", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To determine the involvement of Ca2+ sensitization in b-adrenergic action, we examined the relationship between isometric tension and intracellular Ca2+ concentration (F340/F380) in the inhibitory action of isoproterenol (ISO) against methacholine (MCh)- induced contraction, using fura-2 loaded tracheal smooth muscle.\\nISO reduces contraction more than Ca2+ concentration. This phenomenon was mimicked by forskolin and db-cAMP. In contrast, an inhibition in tension by SKF- 96365, a non-selective Ca2+ channel inhibitor, was associated with that in F340/F380, different from ISO. In the presence of Rp-cAMP, a membrane-permeable inhibitor of protein kinase A (PKA), ISO caused an equivalent relaxation with a less reduction in F340/F380. The effects of ISO were not affected in the presence of Y-27632, an inhibitor of Rho-kinase, and bisindolylmaleimide, an inhibitor of protein kinase C. Even removal of Ca2+ from the extracellular surface, the effects of ISO was not affected. ISO also inhibits high K+-induced contraction without lowering F340/F380. However, response to ISO was completely diminished in the presence of calyculin A, an inhibitor of myosin phosphatase. In conclusion, b-adrenergic action antagonizes Ca2+ sensitization mediated by impairment of myosin phosphatase activity. Moreover, cAMP independent process, G protein direct action, is more potent in inhibiting this Ca2+ sensitization than PKA.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/2750"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Blackwell Scientific Publication", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/j.1365-2222.2006.02412.x", "subitem_relation_type_select": "DOI"}}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "09547894", "subitem_source_identifier_type": "PISSN"}]}, "item_10_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Oguma, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3052", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kume, Hiroaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3053", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Satoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3054", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeda, Naoya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3055", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Honjo, Haruo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3056", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kodama, Itsuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3057", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimokata, Kaoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3058", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamiya, Kaichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3059", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "神谷, 香一郎", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "3060", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Oguma_paper_050118.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "Oguma_paper_050118.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/1357/files/Oguma_paper_050118.pdf"}, "version_id": "a87aa98c-16a0-40e5-9bbb-1e5504870de7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "b-adrenergic receptor agonists", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ca2+ sensitization", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myosin phosphatase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Gs", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rho", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Involvement of reduced sensitivity to Ca2+ in b-adrenergic action on airway smooth muscle", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Involvement of reduced sensitivity to Ca2+ in b-adrenergic action on airway smooth muscle", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["331"], "permalink_uri": "http://hdl.handle.net/2237/2750", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2005-12-27"}, "publish_date": "2005-12-27", "publish_status": "0", "recid": "1357", "relation": {}, "relation_version_is_last": true, "title": ["Involvement of reduced sensitivity to Ca2+ in b-adrenergic action on airway smooth muscle"], "weko_shared_id": -1}