{"created":"2021-03-01T06:07:42.905685+00:00","id":1357,"links":{},"metadata":{"_buckets":{"deposit":"6c77c651-de51-45f6-9e39-9ac9e7c0710b"},"_deposit":{"id":"1357","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1357"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00001357","sets":["329:330:331"]},"author_link":["3052","3053","3054","3055","3056","3057","3058","3059","3060"],"item_10_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Loss of Ca2+ sensitization in b-adrenergic action","subitem_alternative_title_language":"en"}]},"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"191","bibliographicPageStart":"183","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To determine the involvement of Ca2+ sensitization in b-adrenergic action, we examined the relationship between isometric tension and intracellular Ca2+ concentration (F340/F380) in the inhibitory action of isoproterenol (ISO) against methacholine (MCh)- induced contraction, using fura-2 loaded tracheal smooth muscle.\\nISO reduces contraction more than Ca2+ concentration. This phenomenon was mimicked by forskolin and db-cAMP. In contrast, an inhibition in tension by SKF- 96365, a non-selective Ca2+ channel inhibitor, was associated with that in F340/F380, different from ISO. In the presence of Rp-cAMP, a membrane-permeable inhibitor of protein kinase A (PKA), ISO caused an equivalent relaxation with a less reduction in F340/F380. The effects of ISO were not affected in the presence of Y-27632, an inhibitor of Rho-kinase, and bisindolylmaleimide, an inhibitor of protein kinase C. Even removal of Ca2+ from the extracellular surface, the effects of ISO was not affected. ISO also inhibits high K+-induced contraction without lowering F340/F380. However, response to ISO was completely diminished in the presence of calyculin A, an inhibitor of myosin phosphatase. In conclusion, b-adrenergic action antagonizes Ca2+ sensitization mediated by impairment of myosin phosphatase activity. Moreover, cAMP independent process, G protein direct action, is more potent in inhibiting this Ca2+ sensitization than PKA.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/2750"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Scientific Publication","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/j.1365-2222.2006.02412.x","subitem_relation_type_select":"DOI"}}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09547894","subitem_source_identifier_type":"PISSN"}]},"item_10_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oguma, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3052","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kume, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Satoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeda, Naoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honjo, Haruo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodama, Itsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokata, Kaoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamiya, Kaichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3059","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神谷, 香一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"3060","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-16"}],"displaytype":"detail","filename":"Oguma_paper_050118.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Oguma_paper_050118.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/1357/files/Oguma_paper_050118.pdf"},"version_id":"a87aa98c-16a0-40e5-9bbb-1e5504870de7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"b-adrenergic receptor agonists","subitem_subject_scheme":"Other"},{"subitem_subject":"Ca2+ sensitization","subitem_subject_scheme":"Other"},{"subitem_subject":"myosin phosphatase","subitem_subject_scheme":"Other"},{"subitem_subject":"Gs","subitem_subject_scheme":"Other"},{"subitem_subject":"Rho","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Involvement of reduced sensitivity to Ca2+ in b-adrenergic action on airway smooth muscle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Involvement of reduced sensitivity to Ca2+ in b-adrenergic action on airway smooth muscle","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["331"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2005-12-27"},"publish_date":"2005-12-27","publish_status":"0","recid":"1357","relation_version_is_last":true,"title":["Involvement of reduced sensitivity to Ca2+ in b-adrenergic action on airway smooth muscle"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-25T00:52:20.903217+00:00"}