@article{oai:nagoya.repo.nii.ac.jp:00001369,
 author = {KAWANO, Setsuko and KAMBE, Fukushi and KANDA, Kazumi and OHMORI, Sachiko and SEO, Hisao},
 issue = {1/2},
 journal = {Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {Regulation of osteocalcin (OC) gene expression in osteoblasts by estrogen has been controversial. We thus investigated the effect of 17β-estradiol (Ea) on 1α,25-dihydroxyvitamin D_3 (VD_3)-mediated increase in the transcription of OC gene in rat osteoblastic ROS 17/2.8 cells. Treatment of the cells with E_2 or VD_3 alone did not increase OC mRNA. However, combined treatment with E_2 and VD_3 significantly increased the OC mRNA levels, suggesting that VD_3-dependent up-regulation of OC expression requires E_2 action. Since it was demonstrated that treatment with E_2 alone increased the expression of VD_3 receptor mRNA, it was suggested that E_2- mediated increase in the receptor number is contributing to VD_3-mediated increase in OC gene transcription., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {43--44},
 title = {Estrogen Enhances Vitamin D_3-mediated Expression of Osteocalcin mRNA by Increasing Vitamin D_3 Receptor Expression in Osteoblasts},
 volume = {46},
 year = {2002}
}