{"created":"2021-03-01T06:07:43.705603+00:00","id":1370,"links":{},"metadata":{"_buckets":{"deposit":"eaa4d62d-cffd-456a-bc54-17a444c6badc"},"_deposit":{"id":"1370","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1370"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00001370","sets":["329:333:334:335"]},"author_link":["3111","3112","3113","3114","3115","3116"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2","bibliographicPageEnd":"47","bibliographicPageStart":"45","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Thyroid follicular neoplasm is commonly encountered in clinical medicine. However, it is difficult to pathologically differentiate benign from malignant tumors. Recently t (2,3)(ql3; p25), a translocation resulting in the generation of Pax8-PPARγ fusion gene has been reported in American patients with follicular carcinoma with high incidence suggesting that Pax8-PPARγ fusion mRNA could be a molecular marker for the diagnosis of follicular carcinoma. In this study we examined the expression of this fusion gene in follicular carcinomas in Japanese patients. Various thyroid nodules (follicular carcinoma, follicular adenoma, papillary carcinoma, adenomatous goiter and normal tissue) were obtained at surgery in our institute and total RNAs were used to detect the Pax8-PPARγ fusion mRNA by RT-PCR. In all the follicular carcinoma samples, Pax8-PPARγ fusion mRNA was not detected. In all the other samples the expression was also negative. On the other hand, wild type Pax8 mRNA was detected in all the samples and wild type PPARγ mRNA was detected in 83.3% of the follicular adenoma and the adenomatous goiter samples, in 100% of the follicular carcinoma, the papillary carcinoma and the normal tissue samples respectively. In contrast to the previous report, no expression of Pax8-PPARγ fusion gene was detected in follicular carcinomas. Ethnic background may affect the translocation on the pathogenesis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"国立情報学研究所で電子化したコンテンツを使用している。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/2780"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/envm.46.45","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Research Institute of Environmental Medicine, Nagoya University","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"02870517","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HIBI, Yatsuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3111","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAGAYA, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3112","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAMBE, Fukushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3113","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IMAI, Tsuneo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"FUNAHASHI, Hiroomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SEO, Hisao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3116","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-16"}],"displaytype":"detail","filename":"KJ00000034860.pdf","filesize":[{"value":"376.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000034860.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/1370/files/KJ00000034860.pdf"},"version_id":"8d416232-3cfa-4b46-9add-d00c5b2b0409"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Pax8","subitem_subject_scheme":"Other"},{"subitem_subject":"PPARγ","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroid","subitem_subject_scheme":"Other"},{"subitem_subject":"follicular carcinoma","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A specific Translocation of Chromosome 3 Generating Pax8-PPARg Fusion mRNA is Rare in Japanese Patients with Follicular Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A specific Translocation of Chromosome 3 Generating Pax8-PPARg Fusion mRNA is Rare in Japanese Patients with Follicular Carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"1","path":["335"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-01-05"},"publish_date":"2006-01-05","publish_status":"0","recid":"1370","relation_version_is_last":true,"title":["A specific Translocation of Chromosome 3 Generating Pax8-PPARg Fusion mRNA is Rare in Japanese Patients with Follicular Carcinoma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-26T05:57:18.463528+00:00"}