{"created":"2021-03-01T06:07:43.768467+00:00","id":1371,"links":{},"metadata":{"_buckets":{"deposit":"a6db9e2d-a9b3-41c3-8641-8cc4eb13e775"},"_deposit":{"id":"1371","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1371"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00001371","sets":["329:333:334:335"]},"author_link":["3117","3118","3119","3120","3121","3122","3123"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2","bibliographicPageEnd":"51","bibliographicPageStart":"48","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It was reported that accelerated allograft atherosclerosis is associated with usage of cyclosporin A (CsA). Although the immunosuppressive actions of CsA are extensively studied, the mechanisms of this adverse effect remains to be elucidated. We thus studied whether CsA affects the expression of interleukin (IL)-8 in the primary culture of human aortic smooth muscle cells (HASMC) since IL-8 recently has been shown to be a mitogen and a chemoattractant for vascular smooth muscle cells (VSMC). We also studied the effect of epidermal growth factor (EGF) on IL-8 expression because of its potent action of VSMC proliferation in the atherosclerotic lesion. Treatment of HASMC with CsA alone resulted in a significant increase in the IL-8 mRNA level. EGF also increased the mRNA level. CsA together with EGF further increased the IL-8 mRNA level. These results suggested that the CsA-dependent increase in IL- 8 in VSMC could be one of the mechanisms for its induced accelerated allograft atherosclerosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"国立情報学研究所で電子化したコンテンツを使用している。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/2781"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/envm.46.48","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Research Institute of Environmental Medicine, Nagoya University","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"02870517","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MURAKAMI, Ryuichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAMBE, Fukushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MITSUYAMA, Hirohito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OKUMURA, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NIWATA, Satoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMAMOTO, Ryohei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SEO, Hisao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3123","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-16"}],"displaytype":"detail","filename":"KJ00000034861.pdf","filesize":[{"value":"448.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000034861.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/1371/files/KJ00000034861.pdf"},"version_id":"4bfbde81-3cf5-4b4a-b439-7fb89211634a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"interleukin (IL)-8","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclosporin A (CsA)","subitem_subject_scheme":"Other"},{"subitem_subject":"epidermal growth factor (EGF)","subitem_subject_scheme":"Other"},{"subitem_subject":"accelerated allograft atherosclerosis","subitem_subject_scheme":"Other"},{"subitem_subject":"human aortic smooth muscle cells (HASMC)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Epidermal Growth Factor and Cyclosporin A on InterIeukin-8 Gene Expression in Human Aortic Smooth Muscle Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Epidermal Growth Factor and Cyclosporin A on InterIeukin-8 Gene Expression in Human Aortic Smooth Muscle Cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"1","path":["335"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-01-05"},"publish_date":"2006-01-05","publish_status":"0","recid":"1371","relation_version_is_last":true,"title":["Effect of Epidermal Growth Factor and Cyclosporin A on InterIeukin-8 Gene Expression in Human Aortic Smooth Muscle Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-26T05:57:19.509608+00:00"}