{"_buckets": {"deposit": "faa9733a-5886-436e-bdf3-de9d62d2b80d"}, "_deposit": {"id": "1372", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1372"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00001372", "sets": []}, "author_link": ["3124", "3125", "3126", "3127", "3128"], "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1/2", "bibliographicPageEnd": "54", "bibliographicPageStart": "52", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We previously reported that an increase in intracellular calcium by calcium ionophore (A23187) and 4p-phorbol-12β- myristate-13α-acetate (PMA) induced the expression of IL-8 mRNA in human osteoblast-like HOS-TE85 cells and this induction was markedly suppressed by cyclosporin A (CsA). In this study we investigated whether the regulation by A23187, PMA and CsA was occured at a transcriptional level by reporter gene assays. A promoter region spanning from -1460 to +40 of IL-8 gene was PCR- amplified and inserted upstream of a luciferase reporter gene. Various deletion mutants were also constructed. Transfection of the plasmids into HOS-TE85 cells demonstrated that the nucleotides between -133 and -60 base pairs upstream of IL-8 gene are essential and sufficient for its induction by A23187/PMA, and suppression of this induction by CsA.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "国立情報学研究所で電子化したコンテンツを使用している。", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/2782"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.46.52", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of Environmental Medicine, Nagoya University", "subitem_publisher_language": "en"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "02870517", "subitem_source_identifier_type": "PISSN"}]}, "item_9_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "MITSUYAMA, Hirohito", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3124", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAMBE, Fukushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3125", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MURAKAMI, Ryuichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3126", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ISHIGURO, Naoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3127", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SEO, Hisao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3128", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000034862.pdf", "filesize": [{"value": "352.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 352300.0, "url": {"label": "KJ00000034862.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/1372/files/KJ00000034862.pdf"}, "version_id": "a232e35b-954d-4466-ae00-c949c0e2cfda"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "interleukin-8", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cyclosporin A", "subitem_subject_scheme": "Other"}, {"subitem_subject": "human osteoblast", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Analysis of Interieukin-8 Gene Promoter function in Human Osteoblast-like Cells : Regulation by Ca^\u003c2+\u003e-signaling and Cyclosporin A", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Analysis of Interieukin-8 Gene Promoter function in Human Osteoblast-like Cells : Regulation by Ca^\u003c2+\u003e-signaling and Cyclosporin A", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "1", "path": ["335"], "permalink_uri": "https://doi.org/10.18999/envm.46.52", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2006-01-05"}, "publish_date": "2006-01-05", "publish_status": "0", "recid": "1372", "relation": {}, "relation_version_is_last": true, "title": ["Analysis of Interieukin-8 Gene Promoter function in Human Osteoblast-like Cells : Regulation by Ca^\u003c2+\u003e-signaling and Cyclosporin A"], "weko_shared_id": -1}