{"created":"2021-03-01T06:07:43.956972+00:00","id":1374,"links":{},"metadata":{"_buckets":{"deposit":"e5b915a1-80f2-46b3-a077-547bf64d65f7"},"_deposit":{"id":"1374","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1374"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00001374","sets":["329:333:334:335"]},"author_link":["3135","3136","3137","3138","3139","3140","3141"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2","bibliographicPageEnd":"61","bibliographicPageStart":"58","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Central pontine myelinolysis is a serious human demyelinative disorder commonly associated with rapid correction of hyponatremia. Although its precise etiology remains unclear, the blood-brain barrier (BBB) disruption following rapid increase in serum Na^+ considered having an important role in the process. In the present study, therefore, we investigated the preventive effects of various drugs that have been reported to affect the BBB permeability, on osmotic demyelination induced by rapid correction of hyponatremia in mice. Hyponatremia was induced by liquid diet feeding and subcutaneous infusion of l-deamino-8-D-arginine vasopressin, a vasopressin V2 receptor agonist. After 3 days, serum Na^+ was rapidly corrected with hypertonic saline injection. The following drugs were given subcutaneously just before and 5 hours after the correction. Mice in the control group showed serious neurological impairments and most of them died after the correction. Brain sections revealed marked demyelinative lesions in various areas of the brain. However, in the mice treated with aminoguanidine or 7-nitroindazole, a nitric oxide synthase inhibitor, neurological impairments were improved and the survival rates for 24 hours after the correction were markedly increased. Indomethacin, cimetidine and dexamethasone also increased the survival rates after rapid correction. Results from the present study suggest that these drugs may be useful in the prevention of osmotic demyelination after rapid correction of hyponatremia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"国立情報学研究所で電子化したコンテンツを使用している。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/2784"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/envm.46.58","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Research Institute of Environmental Medicine, Nagoya University","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"02870517","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SUGIMURA, Yoshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3135","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAKAGI, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3136","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MURASE, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3137","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HOSHINO, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3138","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAYASAKA, Shizu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3139","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OISO, Yutaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3140","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MURATA, Yoshiharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3141","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-16"}],"displaytype":"detail","filename":"KJ00000034864.pdf","filesize":[{"value":"711.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000034864.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/1374/files/KJ00000034864.pdf"},"version_id":"2bb5cd47-fa33-49c5-a594-bc20eb68c6f6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hyponatremia","subitem_subject_scheme":"Other"},{"subitem_subject":"demyelination","subitem_subject_scheme":"Other"},{"subitem_subject":"blood-brain barrier","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prevention of Demyelination Induced by Rapid correction of Hyponatremia in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prevention of Demyelination Induced by Rapid correction of Hyponatremia in Mice","subitem_title_language":"en"}]},"item_type_id":"9","owner":"1","path":["335"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-01-05"},"publish_date":"2006-01-05","publish_status":"0","recid":"1374","relation_version_is_last":true,"title":["Prevention of Demyelination Induced by Rapid correction of Hyponatremia in Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-26T05:58:41.065370+00:00"}