@article{oai:nagoya.repo.nii.ac.jp:00001377,
 author = {UENO, Tomoyuki and KOZAKI, Yasuko and MIZUMURA, Kazue},
 issue = {1/2},
 journal = {Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {Bradykinin is the most established endogenous algesic substance. It has two receptors subtypes, B1 and B2, which are classified based on their pharmacological properties. It is generally accepted that the B2 receptor (B2R) is normally expressed in many tissues, whereas the B1 receptor (B1R) exists only in limited tissues and is synthesized de novo following tissue injury. We recently demonstrated that B2R-mediated bradykinin responses of peripheral nociceptors were increased in skin-saphenous nerve preparations in vitro in adjuvant inflamed rats, but involvement of B1R could not be confirmed. To examine the possibility that B1R is expressed in cells other than neurons and that we missed BIR-mediated responses while using in vitro preparations, we evaluated the mRNA expression of B1R in rat hind-paw skin and compared it with that of B2R after adjuvant inoculation. B2R mRNA was expressed in control and inflamed animals, and the level of its expression was increased 3 weeks after adjuvant inoculation. B1R mRNA, in contrast to the general belief, was expressed in control animals and increased 3 weeks after adjuvant inoculation, similar to B2R mRNA. Possible meanings of this finding are discussed., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {70--73},
 title = {Increased Expression of mRNA for B1 and B2 Bradykinin Receptors in the Skin of Adjuvant Inoculated Rats},
 volume = {46},
 year = {2002}
}