@article{oai:nagoya.repo.nii.ac.jp:00001378,
 author = {TAGUCHI, Toru and SATO, Jun and MIZUMURA, Kazue},
 issue = {1/2},
 journal = {Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {Few studies have addressed the mechanism of chronic pain originating from musculoskeletal structure, in large part due to the lack of a reliable animal model of chronic muscle pain. The purpose of this study is to try to make an animal model of long-lasting muscle hyperalgesia, using a combination of eccentric muscle work and repeated cold stress (RCS). The mechanical withdrawal threshold in muscle was significantly decreased by RCS with or without eccentric muscle contraction (for at least 7 or 3 days after eccentric exercise or sham exercise, respectively). This result suggests that a combination of eccentric muscle work and RCS could prolong muscle hyperalgesia. However, the duration of the hyperalgesic state in this animal model was not considered long enough to be used in studies on the mechanism of chronic muscle pain. Further trials to elongate the period of hyperalgesia are needed., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {74--76},
 title = {A Combination of Eccentric Muscle Exercise and Repeated Cold Stress (RCS) Induced Prolonged Hyperalgesia : An Attempt to Develop an Animal Model of Chronic Muscle Pain},
 volume = {46},
 year = {2002}
}