@article{oai:nagoya.repo.nii.ac.jp:00001382,
 author = {NIWA, Noriko and YASUI, Kenji and KODAMA, Itsuo},
 issue = {1/2},
 journal = {Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {Mibefradil has been reported to preferentially block T-type Ca^<2+> channel currents in many different tissues including heart with variable potencies. We recorded T-type Ca^<2+> currents (I_<Ca-T>) in early embryonic (9.5 day post coitum (dpc)) mouse ventricular myocytes using a whole-cell patch clamp method and studied the effects of mibefradil. ICa T were inhibited by mibefradil in a concentration- dependent manner with half inhibitory concentration (IC_<50>) at 3.4 ± 0.2 μM. This value is higher than those reported for native adult and neonatal atrial myocytes (0.1-1.5 μM). Factors affecting the mibefradil sensitivity of I_<Ca-T>, in particular different subtypes of α1 subunits, are discussed., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {84--85},
 title = {Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes},
 volume = {46},
 year = {2002}
}