{"created":"2021-03-01T06:07:44.600255+00:00","id":1382,"links":{},"metadata":{"_buckets":{"deposit":"64307365-0b12-4f69-9f05-12cb30d5103c"},"_deposit":{"id":"1382","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1382"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00001382","sets":["329:333:334:335"]},"author_link":["3169","3170","3171"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2","bibliographicPageEnd":"85","bibliographicPageStart":"84","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mibefradil has been reported to preferentially block T-type Ca^<2+> channel currents in many different tissues including heart with variable potencies. We recorded T-type Ca^<2+> currents (I_<Ca-T>) in early embryonic (9.5 day post coitum (dpc)) mouse ventricular myocytes using a whole-cell patch clamp method and studied the effects of mibefradil. ICa T were inhibited by mibefradil in a concentration- dependent manner with half inhibitory concentration (IC_<50>) at 3.4 ± 0.2 μM. This value is higher than those reported for native adult and neonatal atrial myocytes (0.1-1.5 μM). Factors affecting the mibefradil sensitivity of I_<Ca-T>, in particular different subtypes of α1 subunits, are discussed.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"国立情報学研究所で電子化したコンテンツを使用している。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/2792"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/envm.46.84","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Research Institute of Environmental Medicine, Nagoya University","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"02870517","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NIWA, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3169","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YASUI, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KODAMA, Itsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3171","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-16"}],"displaytype":"detail","filename":"KJ00000034872.pdf","filesize":[{"value":"217.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000034872.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/1382/files/KJ00000034872.pdf"},"version_id":"738ab6a2-7205-44f9-9cb0-a44a4855b3ad"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"mibefradil","subitem_subject_scheme":"Other"},{"subitem_subject":"T-type Ca^<2+> channels","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"1","path":["335"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-01-05"},"publish_date":"2006-01-05","publish_status":"0","recid":"1382","relation_version_is_last":true,"title":["Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-26T06:04:32.495050+00:00"}