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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Overexpression of Calpastatin Ameliorates Functional Recovery from Ischemic Injury in the Rat Heart

https://doi.org/10.18999/envm.46.86
https://doi.org/10.18999/envm.46.86
3c9081e0-f1ef-4ff6-bc1c-12727811add4
名前 / ファイル ライセンス アクション
KJ00000034873.pdf KJ00000034873.pdf (322.0 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Overexpression of Calpastatin Ameliorates Functional Recovery from Ischemic Injury in the Rat Heart
言語 en
著者 MAEKAWA, Atsuo

× MAEKAWA, Atsuo

WEKO 3172

en MAEKAWA, Atsuo

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LEE, Jong-Kook

× LEE, Jong-Kook

WEKO 3173

en LEE, Jong-Kook

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MIWA, Keiko

× MIWA, Keiko

WEKO 3174

en MIWA, Keiko

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NAGAYA, Takashi

× NAGAYA, Takashi

WEKO 3175

en NAGAYA, Takashi

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UEDA, Yuichi

× UEDA, Yuichi

WEKO 3176

en UEDA, Yuichi

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KODAMA, Itsuo

× KODAMA, Itsuo

WEKO 3177

en KODAMA, Itsuo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 gene therapy
キーワード
主題Scheme Other
主題 ischemia
キーワード
主題Scheme Other
主題 reperfusion injury
キーワード
主題Scheme Other
主題 calpain
キーワード
主題Scheme Other
主題 calpastatin
キーワード
主題Scheme Other
主題 cardiac troponin I
抄録
内容記述 Calpain, a Ca^<2+>-dependent cytosolic cystein protease, is as an important key protease involved in the ischemic reperfusion injury such as cardiac stunning. Myocardial stunning is a postischemic reversible contractile dysfunction of the heart. We hypothesized that overexpression of calpastatin, an endogenous calpain inhibitor, would attenuate the ischemia/reperfusion injury in the heart. Rat hearts were transfected with human calpastatin gene incorporated into adenovirus vectors. The hearts infected with adenovirus containing lacZ gene were used as controls. The hearts after transfection were heterotopically transplanted into the abdomens of recipient rats and excised on the fourth day after the surgery. The functional recovery from 30-min global ischemia was studied in the isolated hearts perfused in-vitro. The recovery of left ventricular developed pressure, max dP/dt, and min dP/dt during 60-min reperfusion was significantly greater in the calpastatin transfected group than control group heart by gene transfer. Adenovirus-mediated overexpression of calpastatin could be a novel biological storage to improve heart transplantation by minimizing ischemia/reperfusion injury.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.86
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 86-88, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2793
識別子タイプ HDL
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