{"created":"2021-03-01T06:07:44.851783+00:00","id":1386,"links":{},"metadata":{"_buckets":{"deposit":"b9773ddf-27be-44b9-b217-b120d0cbe74a"},"_deposit":{"id":"1386","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1386"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00001386"},"item_9_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2","bibliographicPageEnd":"97","bibliographicPageStart":"95","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University"}]}]},"item_9_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"Bepridil, a potent antiarrhythmic drug, inhibits a variety of cardiac ion channels. Specific block of bepridil on I_<Kr> or I_<Ks>, however, has been controversial and dependent on species and experimental conditions. To clarify this point, we studied the effects of bepridil on I& or I_<Ks> in rabbit ventricular myocytes. Bepridil caused a concentration-dependent inhibition on both currents. IC_<50>s were 0.43 \u00b1 0.20 \u03bcM (n=5) for I& and 0.82 \u00b1 0.32 (\u03bcM (n=7) for I_<Ks>. These results suggest that bepridil may thereby cause an antiarrhythmic action through an inhibition of both 1^ and I_<Ks>.","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"\u5185\u5bb9\u8a18\u8ff0","attribute_value_mlt":[{"subitem_description":"\u56fd\u7acb\u60c5\u5831\u5b66\u7814\u7a76\u6240\u3067\u96fb\u5b50\u5316\u3057\u305f\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u3002","subitem_description_type":"Other"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/2796"}]},"item_9_identifier_registration":{"attribute_name":"ID\u767b\u9332","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/envm.46.95","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"Research Institute of Environmental Medicine, Nagoya University"}]},"item_9_select_15":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_7":{"attribute_name":"ISSN\uff08print\uff09","attribute_value_mlt":[{"subitem_source_identifier":"02870517","subitem_source_identifier_type":"ISSN"}]},"item_9_text_14":{"attribute_name":"\u30d5\u30a9\u30fc\u30de\u30c3\u30c8","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KAMIYA, Kaichiro"}],"nameIdentifiers":[{"nameIdentifier":"3191","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KODAMA, Itsuo"}],"nameIdentifiers":[{"nameIdentifier":"3192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"LU, Zhibo"}],"nameIdentifiers":[{"nameIdentifier":"3193","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-16"}],"displaytype":"detail","filename":"KJ00000034876.pdf","filesize":[{"value":"249.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000034876.pdf","url":"https://nagoya.repo.nii.ac.jp/record/1386/files/KJ00000034876.pdf"},"version_id":"16fd4762-d441-44b3-bca1-4e06b5e7b6f7"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"bepridil","subitem_subject_scheme":"Other"},{"subitem_subject":"potassium channels","subitem_subject_scheme":"Other"},{"subitem_subject":"arrhythmia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Bepridil on I_<Kr> and I_<Ks> of Rabbit Ventricular Myocytes","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"Effects of Bepridil on I_<Kr> and I_<Ks> of Rabbit Ventricular Myocytes"}]},"item_type_id":"9","owner":"1","path":["329/333/334/335"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2006-01-05"},"publish_date":"2006-01-05","publish_status":"0","recid":"1386","relation_version_is_last":true,"title":["Effects of Bepridil on I_<Kr> and I_<Ks> of Rabbit Ventricular Myocytes"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T21:38:04.984083+00:00"}