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Role of Ca^<2+> Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node
https://doi.org/10.18999/envm.46.98
https://doi.org/10.18999/envm.46.9823039948-0cfe-49f4-bbde-206e490b8ee7
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-01-05 | |||||
タイトル | ||||||
タイトル | Role of Ca^<2+> Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node | |||||
言語 | en | |||||
著者 |
HONJO, Haruo
× HONJO, Haruo× INADA, Shin× NIWA, Ryoko× SHIBATA, Nitaro× MITSUI, Kazuyuki× BOYETT, Mark R.× KAMIYA, Kaichiro× KODAMA, Itsuo |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sinoatrial node | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pacemaker activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ryanodine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sarcoplasmic reticulum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | extracellular potential mapping | |||||
抄録 | ||||||
内容記述 | Recent studies using confocal microscopy combined with patch clamping on single sinoatrial (SA) node pacemaker cells suggest that Ca^<2+> release from the sarcoplasmic reticulum (SR) during diastole may play a prominent role in the late phase of pacemaker depolarization. The present study was designed to test this hypothesis in the intact SA node. We investigated the effects of a high concentration of ryanodine, which is known to disable SR Ca^<2+> release, on spontaneous activity of isolated rabbit right atrium including the whole SA node by using an extracellular potential mapping technique. Inhibition of SR Ca^<2+> release by 30 μM ryanodine caused only a moderate reduction of the spontaneous firing rate (by 20.0±2.8 %, n=4) of the intact SA node. This observation is inconsistent with previous data obtained from single pacemaker cells. Physiological significance of SR Ca^<2+> release in the regulation of SA node pacemaker activity is still unsettled. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.46.98 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 02870517 | |||||
書誌情報 |
en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 98-100, 発行日 2002-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/2797 | |||||
識別子タイプ | HDL |