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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Role of Ca^<2+> Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node

https://doi.org/10.18999/envm.46.98
https://doi.org/10.18999/envm.46.98
23039948-0cfe-49f4-bbde-206e490b8ee7
名前 / ファイル ライセンス アクション
KJ00000034877.pdf KJ00000034877.pdf (268.0 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Role of Ca^<2+> Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node
言語 en
著者 HONJO, Haruo

× HONJO, Haruo

WEKO 3194

en HONJO, Haruo

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INADA, Shin

× INADA, Shin

WEKO 3195

en INADA, Shin

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NIWA, Ryoko

× NIWA, Ryoko

WEKO 3196

en NIWA, Ryoko

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SHIBATA, Nitaro

× SHIBATA, Nitaro

WEKO 3197

en SHIBATA, Nitaro

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MITSUI, Kazuyuki

× MITSUI, Kazuyuki

WEKO 3198

en MITSUI, Kazuyuki

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BOYETT, Mark R.

× BOYETT, Mark R.

WEKO 3199

en BOYETT, Mark R.

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KAMIYA, Kaichiro

× KAMIYA, Kaichiro

WEKO 3200

en KAMIYA, Kaichiro

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KODAMA, Itsuo

× KODAMA, Itsuo

WEKO 3201

en KODAMA, Itsuo

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 sinoatrial node
キーワード
主題Scheme Other
主題 pacemaker activity
キーワード
主題Scheme Other
主題 ryanodine
キーワード
主題Scheme Other
主題 sarcoplasmic reticulum
キーワード
主題Scheme Other
主題 extracellular potential mapping
抄録
内容記述 Recent studies using confocal microscopy combined with patch clamping on single sinoatrial (SA) node pacemaker cells suggest that Ca^<2+> release from the sarcoplasmic reticulum (SR) during diastole may play a prominent role in the late phase of pacemaker depolarization. The present study was designed to test this hypothesis in the intact SA node. We investigated the effects of a high concentration of ryanodine, which is known to disable SR Ca^<2+> release, on spontaneous activity of isolated rabbit right atrium including the whole SA node by using an extracellular potential mapping technique. Inhibition of SR Ca^<2+> release by 30 μM ryanodine caused only a moderate reduction of the spontaneous firing rate (by 20.0±2.8 %, n=4) of the intact SA node. This observation is inconsistent with previous data obtained from single pacemaker cells. Physiological significance of SR Ca^<2+> release in the regulation of SA node pacemaker activity is still unsettled.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.98
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 98-100, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2797
識別子タイプ HDL
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