{"_buckets": {"deposit": "f544510a-5e3b-46f1-beb9-5537171c5982"}, "_deposit": {"id": "1387", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1387"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00001387"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1/2", "bibliographicPageEnd": "100", "bibliographicPageStart": "98", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Recent studies using confocal microscopy combined with patch clamping on single sinoatrial (SA) node pacemaker cells suggest that Ca^\u003c2+\u003e release from the sarcoplasmic reticulum (SR) during diastole may play a prominent role in the late phase of pacemaker depolarization. The present study was designed to test this hypothesis in the intact SA node. We investigated the effects of a high concentration of ryanodine, which is known to disable SR Ca^\u003c2+\u003e release, on spontaneous activity of isolated rabbit right atrium including the whole SA node by using an extracellular potential mapping technique. Inhibition of SR Ca^\u003c2+\u003e release by 30 \u03bcM ryanodine caused only a moderate reduction of the spontaneous firing rate (by 20.0\u00b12.8 %, n=4) of the intact SA node. This observation is inconsistent with previous data obtained from single pacemaker cells. Physiological significance of SR Ca^\u003c2+\u003e release in the regulation of SA node pacemaker activity is still unsettled.", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u56fd\u7acb\u60c5\u5831\u5b66\u7814\u7a76\u6240\u3067\u96fb\u5b50\u5316\u3057\u305f\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u3002", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/2797"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.46.98", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of 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"nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SHIBATA, Nitaro"}], "nameIdentifiers": [{"nameIdentifier": "3197", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MITSUI, Kazuyuki"}], "nameIdentifiers": [{"nameIdentifier": "3198", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "BOYETT, Mark R."}], "nameIdentifiers": [{"nameIdentifier": "3199", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAMIYA, Kaichiro"}], "nameIdentifiers": [{"nameIdentifier": "3200", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KODAMA, Itsuo"}], "nameIdentifiers": [{"nameIdentifier": "3201", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-16"}], "displaytype": "detail", "download_preview_message": "", 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