@article{oai:nagoya.repo.nii.ac.jp:00001387,
 author = {HONJO, Haruo and INADA, Shin and NIWA, Ryoko and SHIBATA, Nitaro and MITSUI, Kazuyuki and BOYETT, Mark R. and KAMIYA, Kaichiro and KODAMA, Itsuo},
 issue = {1/2},
 journal = {Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {Recent studies using confocal microscopy combined with patch clamping on single sinoatrial (SA) node pacemaker cells suggest that Ca^<2+> release from the sarcoplasmic reticulum (SR) during diastole may play a prominent role in the late phase of pacemaker depolarization. The present study was designed to test this hypothesis in the intact SA node. We investigated the effects of a high concentration of ryanodine, which is known to disable SR Ca^<2+> release, on spontaneous activity of isolated rabbit right atrium including the whole SA node by using an extracellular potential mapping technique. Inhibition of SR Ca^<2+> release by 30 μM ryanodine caused only a moderate reduction of the spontaneous firing rate (by 20.0±2.8 %, n=4) of the intact SA node. This observation is inconsistent with previous data obtained from single pacemaker cells. Physiological significance of SR Ca^<2+> release in the regulation of SA node pacemaker activity is still unsettled., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {98--100},
 title = {Role of Ca^<2+> Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node},
 volume = {46},
 year = {2002}
}