{"created":"2021-03-01T06:07:44.914535+00:00","id":1387,"links":{},"metadata":{"_buckets":{"deposit":"f544510a-5e3b-46f1-beb9-5537171c5982"},"_deposit":{"id":"1387","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1387"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00001387","sets":["329:333:334:335"]},"author_link":["3194","3195","3196","3197","3198","3199","3200","3201"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2","bibliographicPageEnd":"100","bibliographicPageStart":"98","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent studies using confocal microscopy combined with patch clamping on single sinoatrial (SA) node pacemaker cells suggest that Ca^<2+> release from the sarcoplasmic reticulum (SR) during diastole may play a prominent role in the late phase of pacemaker depolarization. The present study was designed to test this hypothesis in the intact SA node. We investigated the effects of a high concentration of ryanodine, which is known to disable SR Ca^<2+> release, on spontaneous activity of isolated rabbit right atrium including the whole SA node by using an extracellular potential mapping technique. Inhibition of SR Ca^<2+> release by 30 μM ryanodine caused only a moderate reduction of the spontaneous firing rate (by 20.0±2.8 %, n=4) of the intact SA node. This observation is inconsistent with previous data obtained from single pacemaker cells. Physiological significance of SR Ca^<2+> release in the regulation of SA node pacemaker activity is still unsettled.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"国立情報学研究所で電子化したコンテンツを使用している。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/2797"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/envm.46.98","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Research Institute of Environmental Medicine, Nagoya University","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"02870517","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HONJO, Haruo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3194","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"INADA, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NIWA, Ryoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHIBATA, Nitaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MITSUI, Kazuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3198","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"BOYETT, Mark R.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3199","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAMIYA, Kaichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3200","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KODAMA, Itsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3201","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-16"}],"displaytype":"detail","filename":"KJ00000034877.pdf","filesize":[{"value":"268.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000034877.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/1387/files/KJ00000034877.pdf"},"version_id":"12a47d6a-74ed-4e5c-acef-681b525bcd0d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"sinoatrial node","subitem_subject_scheme":"Other"},{"subitem_subject":"pacemaker activity","subitem_subject_scheme":"Other"},{"subitem_subject":"ryanodine","subitem_subject_scheme":"Other"},{"subitem_subject":"sarcoplasmic reticulum","subitem_subject_scheme":"Other"},{"subitem_subject":"extracellular potential mapping","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Role of Ca^<2+> Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of Ca^<2+> Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node","subitem_title_language":"en"}]},"item_type_id":"9","owner":"1","path":["335"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2006-01-05"},"publish_date":"2006-01-05","publish_status":"0","recid":"1387","relation_version_is_last":true,"title":["Role of Ca^<2+> Release from Sarcoplasmic Reticulum in Pacemaker Activity of the Sinoatrial Node"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-26T06:06:21.683759+00:00"}