@article{oai:nagoya.repo.nii.ac.jp:00001388,
 author = {NIWA, Ryoko and LU, Zhibo and HONJO, Haruo and KAMIYA, Kaichiro},
 issue = {1/2},
 journal = {Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {To address the question of whether depolarization or channel opening facilitates drug binding, we studied the voltage- dependent block by bepridil, a positively charged drug, on D540K HERG channels expressed in Xenopus oocytes. At 0 mV, bepridil caused a concentration-dependent inhibition of D540K HERG current with IC_<50>s of 11 ± 3 μM (n=6). At -150 mV, inhibition by bepridil was decreased by 15-fold (161 ±31 μM, n=3). These results suggest that 1) membrane depolarization facilitates block of HERG channels; 2) binding of positively charged drug is augmented at depolarization and diminished at hyperpolarization if the channel remains open., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {101--102},
 title = {Voltage-Dependent Effects of Bepridil on D540K HERG Channels},
 volume = {46},
 year = {2002}
}