@article{oai:nagoya.repo.nii.ac.jp:00001389,
 author = {NIHEI, Motoki and YAMAMOTO, Mitsuru and NIWA, Ryoko and ARAFUNE, Tatsuhiko and MISHIMA, Akira and SHIBATA, Nitaro and SAKUMA, Ichiro and INADA, Hiroshi and HONJO, Haruo and KAMIYA, Kaichiro and KODAMA, Itsuo},
 issue = {1/2},
 journal = {Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University},
 month = {Dec},
 note = {Spiral-type reentry is crucial for genesis and maintenance of the life-threatening ventricular tachyarrhythmia, but little information is available for its pharmacological control. We examined the effects of pilsicainide (Pil), an antiarrhythmic drug having a specific Na^+ channel blocking action, on the spiral dynamics during ventricular tachycardia (VT). Optical action potential signals were recorded with the aid of a voltage-sensitive dye from the epicardial ventricular surface of rabbit heart perfused in-vitro. The endocardial side of the left ventricule was cryoablated to prepare 2-D subepicardial ventricular muscle layers. A high-resolution video-imaging system combined with fiber optic probes was employed for signal recordings. Pil (3 μM) caused a significant reduction of conduction velocity under basal stimulation (SI, 2.5 Hz) without affecting action potential duration. Ventricular tachycardia (VT) induced by cross-field stimulation (S2, 20 V) in the presence of Pil were characterized by slower cycle length (by 22.7 %) and longer electrical diastole (by 107.2 %) compared with controls. Pil also caused an enlargement of core area in stational spiral-type excitation. Possible mechanisms involved in the modulation of spiral-type reentry in the ventricle are discussed., 国立情報学研究所で電子化したコンテンツを使用している。},
 pages = {103--105},
 title = {Na^+ Channel Blockade Causes a Prolongation of Electrical Diastole during Spiral-type Reentry in the Ventricle},
 volume = {46},
 year = {2002}
}