@article{oai:nagoya.repo.nii.ac.jp:00014023,
 author = {KAKINUMA, YOSHIHIRO and MATSUBARA, TATSUAKI and HASHIMOTO, TATSUO and SAKAMOTO, NOBUO},
 issue = {1-2},
 journal = {Nagoya Journal of Medical Science},
 month = {Mar},
 note = {The influence of total ischemia on the formation of products of anaerobic metabolism was investigated in canine hearts in vitro. Contents of organic acids were quantitatively analyzed by gas chromatography-mass spectrometry, and high energy phosphate compounds were determined using the luciferin-Iuciferase enzyme system. During a 10-min period of total ischemia, myocardial creatine phosphate significantly decreased, while ATP remained unchanged as compared with preischemic values. Both 10 min and 60 min of ischemia induced significant increase in tissue succinic acid levels. In contrast, a significant increase in myocardial lactic acid content was only induced with 60 min of ischemia. The data obtained indicate that the accumulation of succinic acid may be regarded as a potential metabolic marker of myocardial total ischemia., 名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成5年9月14日 柿沼善弘氏の博士論文として提出された},
 pages = {35--42},
 title = {MYOCARDIAL METABOLIC MARKERS OF TOTAL ISCHEMIA IN VITRO},
 volume = {57},
 year = {1994}
}