{"created":"2021-03-01T06:21:06.329238+00:00","id":14035,"links":{},"metadata":{"_buckets":{"deposit":"183ff0ff-1bab-4381-baf0-333e59a54620"},"_deposit":{"created_by":17,"id":"14035","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"14035"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00014035","sets":["499:508:509:613"]},"author_link":["98873","98874","98875"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"68","bibliographicPageStart":"61","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To clarify the impairment of carbohydrate metabolism in hyperthyroidism, we performed the oral glucose tolerance test (OGTT) and glucagon tolerance test in ten patients with hyperthyroidism due to Graves' disease (GD) and in ten normal subjects. During OGTT, glucose and insulin values in the GD patients were twice as high as those in the normals. The ratio of cumulative net plasma glucose [ΣPG (0-120 minutes)] and insulin [ΣIRI (0-120 minutes)] was 0.83 ±0.14 and 1.14 ± 0.25 in the GD patients and normals, respectively. During the glucagon tolerance test, plasma glucose showed lower peaks in the GD patients than in the normals. C-peptide reached a peak value at 6 min in the GD patients and at 10 min in the normals. Cyclic AMP response in the GD patients was three times greater than that in the normals. A smaller insulinogenic index and a smaller ΣPG/ΣIRI ratio in the GD patients suggest that the secretion of insulin in GD patients does not meet the demand despite the higher insulin values observed during OGTT. Greater response of cAMP, smaller and earlier peaks of C-peptide and smaller response of glucose to glucagon in the GD patients may suggest a rapid insulin turnover and a reduction of glycogen storage in the liver with hyperthyroidism.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.57.1-2.61","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5712/5712.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MANO, TOSHIKI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98873","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAWAKUBO, AKITOSHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98874","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMAMOTO, MASAHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98875","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"v57n12p61_68.pdf","filesize":[{"value":"451.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v57n12p61_68.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/14035/files/v57n12p61_68.pdf"},"version_id":"2087694c-cd0a-4c79-b5d6-8c4cd006bc4b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glucagon","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucose","subitem_subject_scheme":"Other"},{"subitem_subject":"Graves' Disease","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Glucose and Insulin Metabolism in Patients with Hyperthyroidism Due to Graves' Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Glucose and Insulin Metabolism in Patients with Hyperthyroidism Due to Graves' Disease","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-02-13"},"publish_date":"2012-02-13","publish_status":"0","recid":"14035","relation_version_is_last":true,"title":["Glucose and Insulin Metabolism in Patients with Hyperthyroidism Due to Graves' Disease"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:21:43.911448+00:00"}