@article{oai:nagoya.repo.nii.ac.jp:00014114, author = {OUCHI, NORIYUKI and OHASHI, KOJI and SHIBATA, REI and MUROHARA, TOYOAKI}, issue = {1-2}, journal = {Nagoya Journal of Medical Science}, month = {Feb}, note = {Obesity is closely associated with an increased risk for metabolic and cardiovascular diseases. Adipose tissue produces a number of secretory bioactive substances, also known as adipocytokines or adipokines, which directly affect adjacent or distant organs. Most adipocytokines are pro-inflammatory, thereby promoting the obesity-linked disorders. In contrast, there are a small number of adipocytokines that exhibit antiinflammatory properties. It is now recognized that dysregulated production or secretion of adipocytokines caused by adipocyte dysfunction leads to the development of obesity-linked complications. In this review, we focus on the functional role of several adipocytokines in metabolic and cardiovascular diseases.}, pages = {19--30}, title = {ADIPOCYTOKINES AND OBESITY-LINKED DISORDERS}, volume = {74}, year = {2012} }