{"created":"2021-03-01T06:21:16.042581+00:00","id":14184,"links":{},"metadata":{"_buckets":{"deposit":"bcbc284e-28b4-4046-94fe-4671ac7ae619"},"_deposit":{"created_by":17,"id":"14184","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"14184"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00014184","sets":["499:508:509:616"]},"author_link":["44145","44146","44147","44148","44149"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"142","bibliographicPageStart":"133","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Localization of the tissue inhibitor of metalloproteinases-1 (TIMP-1) was investigated in cultured human gingival fibroblasts by immunohistochemistry. TIMP-1 immunostaining was observed in the cytoplasm of a majority of cells, and in the nucleus of some cells. Depletion of fetal calf serum (FCS) from the culture medium reduced the density of immunoreactive TIMP-1 in the nucleus more remarkably than in the cytoplasm, and the following FCS-induced cell growth was accompanied by a recovery of immuno-reactive TIMP-1 in both the nucleus and the cytoplasm. The frequency of the nuclear TIMP-1-positive cells changed in line with that of PCNA-positive cells and was always much higher than that of S-phase cells, which were estimated by a pulse labelled 5-Bromo-2' deoxyuridine (BrdU). These results suggest a localization of TIMP-1 or a related substance in the nucleus of proliferating human fibroblasts, and its depletion from the nucleus due to an arrest of cell growth.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/16089"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.58.3-4.133","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5834/5834.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"LI, HANG","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NISHIO, KOJI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMASHITA, KYOKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAYAKAWA, TARO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HOSHINO, TAKESHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44149","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"v58n34p133_142.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v58n34p133_142.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/14184/files/v58n34p133_142.pdf"},"version_id":"f3082887-f1fc-4dc9-ad58-d99ecb788857"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TIMP-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Human gingival fibroblast","subitem_subject_scheme":"Other"},{"subitem_subject":"Nuclear localization","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell cycle","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CELL CYCLE-DEPENDENT LOCALIZATION OF TISSUE INHIBITOR OF METALLOPROTEINASES-1 IMMUNOREACTIVITY IN CULTURED HUMAN GINGIVAL FIBROBLASTS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CELL CYCLE-DEPENDENT LOCALIZATION OF TISSUE INHIBITOR OF METALLOPROTEINASES-1 IMMUNOREACTIVITY IN CULTURED HUMAN GINGIVAL FIBROBLASTS","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["616"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-03-08"},"publish_date":"2012-03-08","publish_status":"0","recid":"14184","relation_version_is_last":true,"title":["CELL CYCLE-DEPENDENT LOCALIZATION OF TISSUE INHIBITOR OF METALLOPROTEINASES-1 IMMUNOREACTIVITY IN CULTURED HUMAN GINGIVAL FIBROBLASTS"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:24:33.311257+00:00"}