{"created":"2021-03-01T06:21:33.663561+00:00","id":14449,"links":{},"metadata":{"_buckets":{"deposit":"1fec7cb1-96f0-4304-8b10-103512891673"},"_deposit":{"id":"14449","owners":[],"pid":{"revision_id":0,"type":"depid","value":"14449"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00014449","sets":["499:960:1165"]},"author_link":["44754","44755","44756","44757","44758","44759","44760"],"item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"406","bibliographicPageStart":"400","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Journal of Electron Microscopy","bibliographic_titleLang":"en"}]}]},"item_12_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1993-12-01"}]},"item_12_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"名古屋大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"NAGOYA University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13901","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Bone morphogenetic protein (BMP) partially purified from bovine bone was implanted into the thigh muscles of AKR-strain mice to induce an ectopic endochondral ossification tissue. The extracellular matrix components around the hypertrophic chondrocytes in the induced tissue were examined by electron microscopy and immunohistochemistry for type I collagen. At 14 days after implantation, chondrocytes became hypertrophic with calcifying matrix around them. Some hypertrophic chondrocytes showed no degenerative appearances. They were ringed by a pericellular matrix with no metachromasia which was distinct from the metachromatic cartilage matrix. The localization of type I collagen was demonstrated by immuno-staining in this matrix. Ultrastructurally, ring-shaped matrix consisted of interwoven collagen fibrils on which a D-periodic banding pattern could be discerned. Immunoelectron microscopy demonstrated immunoreactivity of type I collagen on these fibrils. These results suggest that some of the BMP-induced hypertrophic chondrocytes maintain their activity and produce type I collagen-rich matrix before their lacunae are eroded.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_12_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成6年3月25日 服部宇氏の博士論文として提出された","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_12_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2909号"}]},"item_12_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"http://jmicro.oxfordjournals.org/content/42/6/400.abstract"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/16358"}]},"item_12_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_12_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://jmicro.oxfordjournals.org/content/42/6/400.abstract","subitem_relation_type_select":"URI"}}]},"item_12_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Electron Microscopy following peer review. The definitive publisher-authenticated version Journal of Electron Microscopy. v.42, n.6, 1993, p.400-406 is available online at: http://jmicro.oxfordjournals.org/content/42/6/400.abstract.","subitem_rights_language":"en"}]},"item_12_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_12_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-0744","subitem_source_identifier_type":"PISSN"}]},"item_12_text_63":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_text_value":"1993"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hattori, Hisashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawai, Michio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasue, Kazuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizutani, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44757","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Miya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44758","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaneda, Toshio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44759","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hoshino, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"44760","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"k2909.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"k2909.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/14449/files/k2909.pdf"},"version_id":"67fadbbe-12a5-4cef-9e01-16c8ef4a4253"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bone morphogenetic protein","subitem_subject_scheme":"Other"},{"subitem_subject":"hypertrophic chondrocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"immunoelectron microscopy","subitem_subject_scheme":"Other"},{"subitem_subject":"type I collagen","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A correlative immuno-light and electron microscopic study on the type I collagen in the bone morphogenetic protein-induced cartilage","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A correlative immuno-light and electron microscopic study on the type I collagen in the bone morphogenetic protein-induced cartilage","subitem_title_language":"en"}]},"item_type_id":"12","owner":"1","path":["1165"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-05-10"},"publish_date":"2012-05-10","publish_status":"0","recid":"14449","relation_version_is_last":true,"title":["A correlative immuno-light and electron microscopic study on the type I collagen in the bone morphogenetic protein-induced cartilage"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:37:28.913767+00:00"}