{"_buckets": {"deposit": "3dc407df-02de-4e3e-973f-d468733bf8c2"}, "_deposit": {"id": "14757", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14757"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00014757", "sets": ["1165"]}, "author_link": ["45551", "45552"], "item_12_alternative_title_19": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Experimental Investigations ​of Osteogenesis​ and ​Chondrogenesis​ by ​Implant​ of ​BMP-Fibrin​ Glue ​Mixture", "subitem_alternative_title_language": "en"}]}, "item_12_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1990-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "834", "bibliographicPageStart": "824", "bibliographicVolumeNumber": "64", "bibliographic_titles": [{"bibliographic_title": "日本整形外科学会誌", "bibliographic_titleLang": "ja"}]}]}, "item_12_date_granted_64": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "1990-09-01"}]}, "item_12_degree_grantor_62": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "名古屋大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "NAGOYA University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13901", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_12_degree_name_61": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_12_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The influence of fibrin glue on ectopic osteo-chondrogenesis induced by bone morphogenetic protein (BMP), which was extracted from decalcified rabbit long bones, was investigated histologically, radiographically, and electronmicroscopically. The mixtures, consisting of fibrin glue and BMP, were implanted between femoral biceps muscles of AKR mice. They were examined 3 days, 5 days, 1 week, and 2 weeks after implantation, respectively. The fibrin glue did not affect osteo-chondrogenesis by BMP under the mixture conditions, and new bone formation was seen almost in every implant. The fine network of fibrin glue seemed to be effective for adhesion, differenciation of BMP responding cells and was well cooperated on BMP. Fibrin glue network could control the area of osteo-chondrogenesis by BMP. It might be due to restriction of diffusion of BMP. In addition, the whole shape of the newly formed cartilage and bone was influenced by the quantity of Aprotinin administered to fibrin glue. Fibrin glue may be regarded as an effective cooperator of BMP in the case of clinical application of BMP in the future. ", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "本実験の目的は骨形成因子(bone morphogenetic protein 以下 BMP)の骨･軟骨誘導能に与えるフィブリン糊の効果を検討することである. 骨形成因子(BMP)とフィブリン糊の混合サンプルをAKRマウスに移植し,経時的に軟X線学的に検討した. その後に移植サンプルをとりたし組織学的検討および電顕学的検討を行った. フィブリン糊はBMPと混合してもBMPの骨･軟骨誘導能を阻害することはなかった. またフィブリン糊の微細ネット構造はBMP反応細胞の接着,分化, 増殖のための足場となることによりBMPによく協力した. フィブリン糊はBMP移植後の散逸を防止し, その骨･軟骨誘導の範囲を限局するbinderとなった. BMPに対するフィブリン糊の量やそれに含まれるアプロチニンの量を変えることにより新生骨･軟骨の全体的な形状をコントロールしえた. 以上よりBMPが臨床応用される時フィブリン糊はすぐれたBMPの協力物質となる", "subitem_description_language": "ja", "subitem_description_type": "Abstract"}]}, "item_12_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成3年2月1日 服部寿門氏の博士論文として提出された", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_12_dissertation_number_65": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "乙第3911号"}]}, "item_12_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/16684"}]}, "item_12_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本整形外科学会", "subitem_publisher_language": "ja"}]}, "item_12_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_12_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0021-5325", "subitem_source_identifier_type": "PISSN"}]}, "item_12_text_63": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_text_value": "1990"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "服部, 寿門", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "45551", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HATTORI, TOSHIKADO", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45552", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "o3911.pdf", "filesize": [{"value": "3.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 3100000.0, "url": {"label": "o3911.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/14757/files/o3911.pdf"}, "version_id": "280a920d-eda9-483b-bbee-9ad1d23a0c78"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "BMP : Bone Morphogenetic Protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Fibrin glue", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BMP-fibrin glue mixture", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Aprotinin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Osteo-chondrogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "骨形成因子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "フィブリン糊", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BMPフィブリン糊混合剤", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アプロチニン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "骨軟骨誘導能", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "骨形成因子 (Bone Morphogenetic Protein-BMP) とフィブリン糊混合剤の骨・軟骨誘導能に関する研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "骨形成因子 (Bone Morphogenetic Protein-BMP) とフィブリン糊混合剤の骨・軟骨誘導能に関する研究", "subitem_title_language": "ja"}]}, "item_type_id": "12", "owner": "1", "path": ["1165"], "permalink_uri": "http://hdl.handle.net/2237/16684", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2012-07-27"}, "publish_date": "2012-07-27", "publish_status": "0", "recid": "14757", "relation": {}, "relation_version_is_last": true, "title": ["骨形成因子 (Bone Morphogenetic Protein-BMP) とフィブリン糊混合剤の骨・軟骨誘導能に関する研究"], "weko_shared_id": -1}