{"_buckets": {"deposit": "3dc407df-02de-4e3e-973f-d468733bf8c2"}, "_deposit": {"id": "14757", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14757"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00014757"}, "item_12_alternative_title_19": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u8a00\u8a9e\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Experimental  Investigations\u3000\u200bof\u3000Osteogenesis\u200b and \u200bChondrogenesis\u200b by \u200bImplant\u200b of \u200bBMP-Fibrin\u200b Glue \u200bMixture"}]}, "item_12_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1990-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "834", "bibliographicPageStart": "824", "bibliographicVolumeNumber": "64", "bibliographic_titles": [{"bibliographic_title": "\u65e5\u672c\u6574\u5f62\u5916\u79d1\u5b66\u4f1a\u8a8c"}]}]}, "item_12_date_granted_64": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "1990-09-01"}]}, "item_12_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The influence of fibrin glue on ectopic osteo-chondrogenesis induced by bone morphogenetic protein (BMP), which was extracted from decalcified rabbit long bones, was investigated histologically, radiographically, and electronmicroscopically. The mixtures, consisting of fibrin glue and BMP, were implanted between femoral biceps muscles of AKR mice. They were examined 3 days, 5 days, 1 week, and 2 weeks after implantation, respectively. The fibrin glue did not affect osteo-chondrogenesis by BMP under the mixture conditions, and new bone formation was seen almost in every implant. The fine network of fibrin glue seemed to be effective for adhesion, differenciation of BMP responding cells and was well cooperated on BMP. Fibrin glue network could control the area of osteo-chondrogenesis by BMP. It might be due to restriction of diffusion of BMP. In addition, the whole shape of the newly formed cartilage and bone was influenced by the quantity of Aprotinin administered to fibrin glue. Fibrin glue may be regarded as an effective cooperator of BMP in the case of clinical application of BMP in the future. \u672c\u5b9f\u9a13\u306e\u76ee\u7684\u306f\u9aa8\u5f62\u6210\u56e0\u5b50(bone morphogenetic protein \u4ee5\u4e0b BMP)\u306e\u9aa8\uff65\u8edf\u9aa8\u8a98\u5c0e\u80fd\u306b\u4e0e\u3048\u308b\u30d5\u30a3\u30d6\u30ea\u30f3\u7cca\u306e\u52b9\u679c\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3067\u3042\u308b. \u9aa8\u5f62\u6210\u56e0\u5b50(BMP)\u3068\u30d5\u30a3\u30d6\u30ea\u30f3\u7cca\u306e\u6df7\u5408\u30b5\u30f3\u30d7\u30eb\u3092AKR\u30de\u30a6\u30b9\u306b\u79fb\u690d\u3057,\u7d4c\u6642\u7684\u306b\u8edfX\u7dda\u5b66\u7684\u306b\u691c\u8a0e\u3057\u305f. \u305d\u306e\u5f8c\u306b\u79fb\u690d\u30b5\u30f3\u30d7\u30eb\u3092\u3068\u308a\u305f\u3057\u7d44\u7e54\u5b66\u7684\u691c\u8a0e\u304a\u3088\u3073\u96fb\u9855\u5b66\u7684\u691c\u8a0e\u3092\u884c\u3063\u305f. \u30d5\u30a3\u30d6\u30ea\u30f3\u7cca\u306fBMP\u3068\u6df7\u5408\u3057\u3066\u3082BMP\u306e\u9aa8\uff65\u8edf\u9aa8\u8a98\u5c0e\u80fd\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306f\u306a\u304b\u3063\u305f. \u307e\u305f\u30d5\u30a3\u30d6\u30ea\u30f3\u7cca\u306e\u5fae\u7d30\u30cd\u30c3\u30c8\u69cb\u9020\u306fBMP\u53cd\u5fdc\u7d30\u80de\u306e\u63a5\u7740,\u5206\u5316, \u5897\u6b96\u306e\u305f\u3081\u306e\u8db3\u5834\u3068\u306a\u308b\u3053\u3068\u306b\u3088\u308aBMP\u306b\u3088\u304f\u5354\u529b\u3057\u305f. \u30d5\u30a3\u30d6\u30ea\u30f3\u7cca\u306fBMP\u79fb\u690d\u5f8c\u306e\u6563\u9038\u3092\u9632\u6b62\u3057, \u305d\u306e\u9aa8\uff65\u8edf\u9aa8\u8a98\u5c0e\u306e\u7bc4\u56f2\u3092\u9650\u5c40\u3059\u308bbinder\u3068\u306a\u3063\u305f. 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