@phdthesis{oai:nagoya.repo.nii.ac.jp:00014766, author = {Kitagawa, Yoshimi and Nimura, Yuji and Kanda, Hiroshi and Uematsu, Toshio and Kamiya, Satoaki and Machiki, Yuichi and Watanabe, Tomohito}, month = {Jan}, note = {This study was conducted to examine how the effects of dopamine and dobutamine on hepatic blood flow were influenced by obstructive jaundice in a conscious canine model. Prior to biliary obstruction, portal venous blood flow (PVF) increased in response to the infusion of either dopamine or dobutamine: dopamine infused at 8 μg/kg per min produced an increase of 19±0% in PVF, while dobutamine infused at 16 μg/kg per min produced an increase of 30±2%. Although hepatic arterial blood flow (HAF) decreased dose-dependently in response to the infusion of dopamine, no significant change was observed in HAF in response to any dose of dobutamine. Obstructive jaundice attenuated or completely abolished the PVF-increasing effect of dopamine, whereas it did not significantly alter the effect of dobutamine on hepatic blood flow. In dogs with obstructive jaundice, dopamine at 16 μg/kg per min produced a decrease of 17±3% in PVF. These findings suggest that dobutamine is more effective than dopamine for increasing hepatic blood flow in patients with obstructive jaundice., 名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成7年12月20日 北川喜己氏の博士論文として提出された}, school = {名古屋大学, NAGOYA University}, title = {The effects of intravenously infused catecholamines on hepatic blood flow in conscious dogs with experimental obstructive jaundice}, year = {1996} }