{"created":"2021-03-01T06:21:56.436549+00:00","id":14799,"links":{},"metadata":{"_buckets":{"deposit":"052a5699-0d71-4221-a309-4c860b948c1c"},"_deposit":{"created_by":17,"id":"14799","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"14799"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00014799","sets":["499:508:509:1403"]},"author_link":["45707"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"232","bibliographicPageStart":"217","bibliographicVolumeNumber":"74","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hepatitis B virus (HBV) is susceptible to the cellular immune responses, especially to the signal of interferon (IFN)-γ. The action of IFN-γ is pleiotropic, and causes downregulation of HBV in protein, RNA, and possibly DNA levels. Therefore, therapeutic vaccination to induce cellular immune responses to HBV is a promising approach for controlling chronic HBV infection. A number of clinical trials with this approach have been conducted to date, however, they have not been as successful as initially expected.T-cell exhaustion induced by the excessive HBV antigens caused by persistent infection is thought to be one of the main causes of poor responses to therapeutic vaccination. In this review, the mechanisms behind immunoregulation of HBV replication and immunodysfunction during chronic HBV infection are summarized, and novel approaches to improve the efficacy of therapeutic vaccination, from basic research to clinical trials, are introduced.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/16732"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.74.3-4.217","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7434/7434.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ISHIKAWA, TETSUYA","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45707","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"01_Ishikawa.pdf","filesize":[{"value":"540.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"01_Ishikawa.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/14799/files/01_Ishikawa.pdf"},"version_id":"cc6959da-e356-4eb7-b6e5-1c197608b22b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"chronic hepatitis B","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon-g","subitem_subject_scheme":"Other"},{"subitem_subject":"adaptive immune response","subitem_subject_scheme":"Other"},{"subitem_subject":"therapeutic vaccination","subitem_subject_scheme":"Other"},{"subitem_subject":"T-cell exhaustion","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"IMMUNOREGULATION OF HEPATITIS B VIRUS INFECTION : RATIONALE AND CLINICAL APPLICATION","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IMMUNOREGULATION OF HEPATITIS B VIRUS INFECTION : RATIONALE AND CLINICAL APPLICATION","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1403"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-08-28"},"publish_date":"2012-08-28","publish_status":"0","recid":"14799","relation_version_is_last":true,"title":["IMMUNOREGULATION OF HEPATITIS B VIRUS INFECTION : RATIONALE AND CLINICAL APPLICATION"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:25:25.101208+00:00"}