{"created":"2021-03-01T06:22:00.912559+00:00","id":14869,"links":{},"metadata":{"_buckets":{"deposit":"e7c6943e-ca7b-472c-b197-08762768448f"},"_deposit":{"id":"14869","owners":[],"pid":{"revision_id":0,"type":"depid","value":"14869"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00014869","sets":["499:960:1165"]},"author_link":["45947","45948","45949","45950","45951","45952","45953","45954","45955","45956","45957","45958"],"item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"456","bibliographicPageStart":"444","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Environmental Health and Preventive Medicine","bibliographic_titleLang":"en"}]}]},"item_12_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2012-11-01"}]},"item_12_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"名古屋大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Nagoya University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13901","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: The aim of this study was to identify the molecular mechanisms underlying high-fat and high-cholesterol (HFC) diet-induced steatohepatitis and associated liver fibrosis progression in a novel stroke-prone, spontaneously hypertensive 5/Dmcr (SHRSP5/Dmcr) rat model. Methods: SHRSP5/Dmcr rats were given the control or HFC-diet for 2, 8, and 16 weeks. Plasma and hepatic gene expression of key molecules involved in fatty acid oxidation, inflammation, oxidative stress, and fibrosis were subsequently analyzed. Results: Rats fed the HFC-diet showed increased plasma tumor necrosis factor-α (TNF-α) and hepatic p50/p65 signals, but reduced hepatic Cu2+/Zn2+-superoxide dismutase across the treatment period and reduced plasma total adiponectin at 8 weeks. In HFC-diet-fed rats, transforming growth factor-β1 (TGF-β1) was elevated prior to the appearance of obvious liver fibrosis pathology at 2 weeks, followed by elevations in platelet-derived growth factor-B (PDGF-B) and α-smooth muscle actin (α-SMA), corresponding to evident liver fibrosis, at 8 weeks and by α1 type I collagen production at 16 weeks. The HFC-diet increased hepatic total cholesterol accumulation, although hepatic triglyceride declined by 0.3-fold from 2 to 16 weeks due to reduced hepatic triglyceride synthesis, as suggested by the diacylglycerol acyltransferase 1 and 2 measurements. Conclusions: TNF-α and p50/p65 molecular signals appeared to be major factors for HFC-diet-induced hepatic inflammation and oxidative stress facilitating liver disease progression. While the up-regulation of TGF-β1 prior to the appearance of any evident liver fibrosis could be an early signal for progressive liver fibrosis, elevated PDGF-B and α-SMA levels signified evident liver fibrosis at 8 weeks, and subsequent increased α1 type I collagen production and reduced triglyceride synthesis indicated extensive liver fibrosis at 16 weeks in this novel SHRSP5/Dmcr model.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_12_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成24年4月27日 森谷隆氏の博士論文として提出された","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"First published online: 2012-03-10","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_12_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第9756号"}]},"item_12_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://dx.doi.org/10.1007/s12199-012-0273-y"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/16803"}]},"item_12_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_12_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12199-012-0273-y","subitem_relation_type_select":"DOI"}}]},"item_12_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"The final publication is available at www.springerlink.com","subitem_rights_language":"en"}]},"item_12_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_12_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1342-078X","subitem_source_identifier_type":"PISSN"}]},"item_12_text_63":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_text_value":"2012"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Moriya, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamori, Kazuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naito, Hisao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanagiba, Yukie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamagishi, Nozomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamada, Hazuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jia, Xiaofang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchikura, Satoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikeda, Katsumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamori, Yukio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45957","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tamie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"45958","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"k9756.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"k9756.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/14869/files/k9756.pdf"},"version_id":"1471bef4-c0dd-499f-b4f4-dffa4a9bfe41"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Steatohepatitis","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-α","subitem_subject_scheme":"Other"},{"subitem_subject":"NF-κb","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibrosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat","subitem_title_language":"en"}]},"item_type_id":"12","owner":"1","path":["1165"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-10-01"},"publish_date":"2012-10-01","publish_status":"0","recid":"14869","relation_version_is_last":true,"title":["Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:02:21.302873+00:00"}