@article{oai:nagoya.repo.nii.ac.jp:00015275,
 author = {NAGASAKA, TETSUO},
 issue = {2-4},
 journal = {Nagoya Journal of Medical Science},
 month = {Mar},
 note = {Metabolic rate (M), tissue conductance (k), rectal (Tre) and mean skin temperature (Ts) were measured in normal (CONT) and cold acclimated (CA) rabbits after steady state for a given ambient temperature (Tα) from 5 to 35°C. Below Tα=15°C, Tre of CONT decreased considerably, while Tre of CA was maintained within a normal range. The rate of change in Ts for each degree change in Tα (below Tα=15°C) was smaller in CA. M, always higher in CA than in CONT at any Tα, increased more than twice the basal value (2.54 W/kg±0.06 SE for CONT and 2.85 W/kg±0.07 SE for CA at Tα=25°C) during cold exposure (Tα= 5°C). Though k was relatively constant at Tα=25-5°C, it increased considerably at Tα=35°C. The value for CA was higher than that for CONT at any Tα. Perfusion of norepinephrine (NE, 3 μg/kg·min for 30-min) in curarized rabbits caused bradycardia, which was more conspicuous in CONT. NE caused an increase in M (ca. 18%) in CA without any change in CONT (p<0.01). The increase in M was not limited to the duration of NE perfusion. NE did not change body temperatures except for slight rise of Ts in CA. During cold exposure, body temperatures decreased continuously in the curarized rabbits. M increased slightly during the initial 30-40 min of cold exposure in CA. The results confirmed that the rabbit acclimates to cold by enhancing nonshivering thermogenesis mediated by NE, as well as by improving insulation.},
 pages = {79--89},
 title = {Thermoregulatory Responses in Normal and Cold Acclimated Rabbits},
 volume = {36},
 year = {1974}
}