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Effect of Heterologous Transplantation of H4-II-E Rat Hepatoma Cells into the Cheek Pouch of Irradiated Hamster
https://doi.org/10.18999/nagjms.37.1-2.1
https://doi.org/10.18999/nagjms.37.1-2.1d2c18f64-da15-4e5f-afa2-a0f45689befc
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-01-18 | |||||
タイトル | ||||||
タイトル | Effect of Heterologous Transplantation of H4-II-E Rat Hepatoma Cells into the Cheek Pouch of Irradiated Hamster | |||||
著者 |
MURAGISHI, HIDEHIKO
× MURAGISHI, HIDEHIKO× CORPENING, BARBARA× BOTTOMLEY, RICHARD H. |
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抄録 | ||||||
内容記述 | A series of transplant-explant experiments using the H 4-II-E rat hepatoma cell line and golden hamsters have been carried out. The original tissue culture cells. which had a modal chromosome number of 51, implanted into the cheek pouches of irradiated hamster (400 rads) produced tumors which were typical hepatomas histologically. Cells from these tumors were placed back into tissue culture and were transferred twice more into the cheek pouches of irradiated animals and tissue culture. These were termed the first. second and third selection, respectively. At each stage of selection. chromosome counts, karyotypes and histological and biological characteristics of the cells were determined. The explant from the first selection tumors and that from the second selection tumors were found. to have 53 and 54 chromosome modes, respectively. Two explants derived from separate animals in the third stage of selection each showed different modes of chromosome number (53 and 54). The explants with a modal chromosome number of 54 had a more homogeneous karyotype than those with 53 chromosomes, and the former appeared to be less malignant than the latter. as judged by transplantability, growth rate of the cells in the hydrocortisone treated hamster and the isologous host and histological appearance of the tumors. A possible relationship between cytogenetic variations and biological variations in the cells is discussed. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.37.1-2.1 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
Nagoya Journal of Medical Science 巻 37, 号 1-2, p. 1-22, 発行日 1974-08 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/3712/3712.html | |||||
識別子タイプ | URI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/17294 | |||||
識別子タイプ | HDL |