@article{oai:nagoya.repo.nii.ac.jp:00015281,
 author = {KOBAYASHI, HISANDO and TAUCHI, HISASHI},
 issue = {3-4},
 journal = {Nagoya Journal of Medical Science},
 month = {Mar},
 note = {Ten cases of human hepatoma obtained at surgery and autopsy were studied enzyme-histochemically, and compared with gastric carcinoma, intrahepatic bile duct carcinoma and prostate carcinoma. The enzymes studied were glucose-6-phosphatase, acid phosphatase, alkaline phosphatase, succinic dehydrogenase, cytochrome oxidase, and peroxidase. In conventional stained sections, case 1 was grade I and II hepatocellular carcinoma by the classification of Edmondson. Case 2 and case 3 were grade IV or more malignant than grade III, and the remaining were almost all grade III. Case 1, in which all enzymes except alkaline phosphatase were histochemically demonstrated in hepatoma cells, could belong to such minimum deviation hepatoma. Acid phosphatase was demonstrated as more prominent granules in the hepatocellular carcinoma cells of all cases. Succinic dehydrogenase was noticed to be very weak or negative except for case 1, but cytochrome oxidase was positive in all cases. Glucose-6-phosphatase was histochemically demonstrated in all cases examined, but the activity was low except for case 1, and negative in control cancer cases. Peroxidase was generally low in activity in all hepatomas except for case 1. The intensity of glucose-6-phosphatase and peroxidase activities in the present human hepatomas may be related to a more detailed and accurate differentiation of hepatocellular carcinoma than the classification of Edmondson by conventional stained sections.},
 pages = {45--57},
 title = {Histochemical Study on the Activity of the Enzymes in Human Hepatomas},
 volume = {37},
 year = {1975}
}