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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 39(1-2)

Bone Marrow δ-Aminolevulinic Acid Synthetase Activity in Hematological Disorders

https://doi.org/10.18999/nagjms.39.1-2.21
https://doi.org/10.18999/nagjms.39.1-2.21
10e80283-92cb-4569-a961-9d60f3053eba
名前 / ファイル ライセンス アクション
v39n12p21_31.pdf v39n12p21_31.pdf (734.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-01-21
タイトル
タイトル Bone Marrow δ-Aminolevulinic Acid Synthetase Activity in Hematological Disorders
著者 TANAKA, MASAO

× TANAKA, MASAO

WEKO 46691

TANAKA, MASAO

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抄録
内容記述 An improved radiochemical method to measure the δ-aminoJevulinic acid (ALA) synthetase activity in human bone marrow erythroblasts by incubating bone marrow cell homogenate with 14C-succinate and succinyl CoA generating system has been reported. Studies were made to obtain the optimal conditions for the enzyme assay and to confirm the reliability of the assay procedures.
ALA-synthetase in erythroblasts was found to be decreased in all 3 cases of iron deficiency anemia and 3 cases of β-thalassemia minor. In 5 cases of idiopathic sideroblastic anemia, the enzyme activity was markedly decreased. A case of sideroblastic anemia, who restored normal erythropoiesis following the administration of pyridoxal phosphate (PLP) showed low PLP level in serum & blood as well as in vivo evidence of PLP deficiency and an in vitro stimulation of ALAsynthetase activity by PLP. Erythroblasts of 4 patients with erythroleukemia showed diminished bone marrow ALA-synthetase activity.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.39.1-2.21
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 39, 号 1-2, p. 21-31, 発行日 1977-01
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/3912/3912.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17322
識別子タイプ HDL
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