@article{oai:nagoya.repo.nii.ac.jp:00015335,
 author = {YASUE, MANJI},
 issue = {3-4},
 journal = {Nagoya Journal of Medical Science},
 month = {Mar},
 note = {An attempt was made to study the influences of anti-cancer agents on transtracheal tumor transplantation. For a preliminary investigation by the use of autoradiographic technique, the influence of Mitomycin C (MMC) was studied on DNA synthesis in epithelial cells of the rat trachea, which were regenerating following mechanical injury. A rapid increase of DNA synthesis in regenerating epithelial cells was observed from 6 hours to 18 hours after the injury. Maximum level of DNA synthesis was maintained from 18 to 48 hours, then decreased to the same level as observed at 6 hours. After intraperitoneal administration of MMC in the dose of 1/4 or 1/2 LD50 immediately after the injury, DNA synthesis was remarkably depressed from 6 hours to 48 hours, whereas, the value at 72 hours increased significantly as compared with the control. In case of frequent intermittent administration of MMC at 1/4 LD50 four time every other day before and once immediately after the injury, DNA synthesis was depressed for up to 72 hours and did not recover. Labelling index with 3H-Thymidine of epithelial cells of the normal trachea and bronchia was 0.5% and 0.4% respectively, and influence of MMC was not recognized except in the case of the above mentioned frequent intermittent administration. When subcutaneously growing tissue of Yoshida sarcoma was inoculated into the bronchia of rats by inhalation transtracheally, transplantation was not established in the bronchia. By frequent intermittent administration of MMC to the animals prior to inhalation, however, transtracheal transplantation was established at a rate of 30%. By microscopic study tumor cells were found to infIltrate the bronchial wall where the mucosa of the bronchia plugged by tumor tissue had peeled off. Proliferation of the tumor cells in the bronchia was manifested by the intracellular incorporation of 3H-Thymidine in the peripheral area of the tumor tissue which had plugged the bronchial canal.},
 pages = {61--70},
 title = {The Effects of Anti-Cancer Agents on Transtracheal Tumor Transplantation},
 volume = {40},
 year = {1978}
}