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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 40(3-4)

Interaction between Bleomycin and Glutathione in Cancer-Bearing Animals

https://doi.org/10.18999/nagjms.40.3-4.81
https://doi.org/10.18999/nagjms.40.3-4.81
fc1bb578-edbc-43ac-abd4-dfde1388d07d
名前 / ファイル ライセンス アクション
v40n34p81_91.pdf v40n34p81_91.pdf (795.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-01-23
タイトル
タイトル Interaction between Bleomycin and Glutathione in Cancer-Bearing Animals
著者 KANEDA, TOSHIO

× KANEDA, TOSHIO

WEKO 46745

KANEDA, TOSHIO

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ICHIKAWA, HITOSHI

× ICHIKAWA, HITOSHI

WEKO 46746

ICHIKAWA, HITOSHI

Search repository
抄録
内容記述 We performed an experiment on the anticancer effect of Bleomycin and Glutathione administered simultaneously in tumor bearing mice. 1) The radioactivity of 35S-Glutathione in organs tended to be lower after the simultaneous administration of the labelled Glutathione and Bleomycin than when the labelled Glutatione was given alone. 2) The reaction of Glutathione and Bleomycin in vivo depends upon the quantitative ratio of the two substances. 3) In cancer-bearing mice a comparison was made of anticancer effectiveness between Bleomycin used alone and in combination with Glutathione. During an initial 60 day period treatment with Bleomycin alone produced an excellent anticancer effect and also provided a marked life prolonging effect when compared with control. These effects in the Bleomycin + Glutathione group were no better than in the control group. 4) Past the 60th day of treatment (after 30 doses of Bleomycin or Glutathione were given) fatalities occurred frequently in the Bleomycin group due to the drug toxicity, while in the Bleomycin + Glutathione group a greater increment of survival time was attained due to a detoxifying effect of Glutathione.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.40.3-4.81
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 40, 号 3-4, p. 81-91, 発行日 1978-03
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4034/4034.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17355
識別子タイプ HDL
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