@article{oai:nagoya.repo.nii.ac.jp:00015345,
 author = {SAKAMOTO, JUNICHI and KONDO, TATSUHEI and KAMEl, HIDEO and ICHlHASHl, HIDEHITO and YAMAMURA, YOSHITAKA},
 issue = {1-2},
 journal = {Nagoya Journal of Medical Science},
 month = {Dec},
 note = {To clarify the effect of large dose intratumoral administration of OK-432, experimental and clinical investigations were perfomed. In the experimental study, 250 KE/Kg OK-432 was administered into S-180 sarcoma in ddN mice. Mice treated by OK-432 showed significant increase in delayed hypersensitivity reaction and elongation in the survival times. In the clinical study, 50 KE OK-432 was injected intratumorally during the surgery for the advanced and inoperable malignancy. PHA and PPD skin test reactions, IgG titers, and lymphocyte counts were elevated in the group received the large dose of OK-432. The treatment seemed to contribute to the prolongation of survival times during 3 months after the operation.},
 pages = {27--36},
 title = {The Effect of Large Dose Intratumoral Administration of OK-432 in Advanced Cancer Patients},
 volume = {42},
 year = {1979}
}