{"_buckets": {"deposit": "de7a0e13-ad69-4083-befd-2a8a3719e153"}, "_deposit": {"id": "15368", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "15368"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00015368"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1981-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3-4", "bibliographicPageEnd": "100", "bibliographicPageStart": "89", "bibliographicVolumeNumber": "43", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The antitumor activities of seventeen antitumor alkylating agents have been studied in the xenograft of human mammary carcinoma transplanted in nude mice (MX-1). The drugs employed in this study were; cyclophosphamide, ifosfamide, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), 1-(2-chloroethyl)- 3-(4-methylcyclohexyl)-1-nitrosourea (me-CCNU), 2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy- D-glucopyranose (chlorozotocin, or DCNU), 3[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU), 1-(2-chloroethyl)-3-(methyl \u03b1-D-glucopyranos-6-yl)-1-nitrosourea (MCNU), 1-(2-chloroethyl)-3-(\u03b2-D-glucopyranosyl)-1-nitrosourea(GANU), 4-[bis(2- chloroethyl)amino]-L-phenylalanine (L-PAM), chlorambucil, busulfan, Bis(3-methylsulfonyloxypropyl)amine p-toluenesulfonate (864-T), N, N\u0027, N\"-triethylenimino thiophosphoramide (thio-TEPA), carbazilquinone, dibromomannitol, procarbazine and 5-(3, 3-dimethyl-1-triazeno) imidazole-4- carboxamide (DTIC). Cyclophosphamide, ifosfamide, chlorozotocin, ACNU, MCNU, GANU, 864-T, thio-TEPA, carbazilquinone and DTIC were administered intravenously through a tail vein, and the others were given intraperitoneally. Among these seventeen antitumor alkylating agents, the most active compounds (maximum rate of tumor regression : \u22679O%) are cyclophosphamide, ACNU, L-PAM, chlorambucil, thio-TEPA, carbazilquinone and dibromomannitol. Another group of compounds showed moderate activity (maximum rate of tumor regression: 89-50%), including ifosfamide, CCNU, MCNU, GANU, busulfan, 864-T and procarbazine. The remaining three compounds showed less than moderate activity (\u226649%) and were therefore considered to be inactive. These results in nude mouse-human tumor xenograft system correspond to clinically observed patterns of chemotherapy sensitivity in patients with breast cancer.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "URI", "subitem_identifier_uri": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4334/4334.html"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/17385"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.43.3-4.89", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN\uff08Online\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "ISSN"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "INOUE, KATSUHIRO"}], "nameIdentifiers": [{"nameIdentifier": "46830", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "FUJIMOTO, SHUICHI"}], "nameIdentifiers": [{"nameIdentifier": "46831", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OGAWA, MAKOTO"}], "nameIdentifiers": [{"nameIdentifier": "46832", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "v43n34p89_100.pdf", "filesize": [{"value": "718.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 718200.0, "url": {"label": "v43n34p89_100.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/15368/files/v43n34p89_100.pdf"}, "version_id": "6ee7d88d-3bd5-4f50-bc0e-c4dc3ff37e3a"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Experimental chemotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Nude mice", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Xenograft", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Human mammary carcinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Antitumor alkylating agents", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Antitumor Activities of Seventeen Alkylating Agents Against Human Mammary Carcinoma (MX-1) in Nude Mice", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Antitumor Activities of Seventeen Alkylating Agents Against Human Mammary Carcinoma (MX-1) in Nude Mice"}]}, "item_type_id": "9", "owner": "1", "path": ["499/508/509/1449"], "permalink_uri": "https://doi.org/10.18999/nagjms.43.3-4.89", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2013-01-24"}, "publish_date": "2013-01-24", "publish_status": "0", "recid": "15368", "relation": {}, "relation_version_is_last": true, "title": ["Antitumor Activities of Seventeen Alkylating Agents Against Human Mammary Carcinoma (MX-1) in Nude Mice"], "weko_shared_id": 3}