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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 43(3-4)

Antitumor Activities of Seventeen Alkylating Agents Against Human Mammary Carcinoma (MX-1) in Nude Mice

https://doi.org/10.18999/nagjms.43.3-4.89
https://doi.org/10.18999/nagjms.43.3-4.89
ad963698-ce8c-42a2-923b-34840c5ed5ec
名前 / ファイル ライセンス アクション
v43n34p89_100.pdf v43n34p89_100.pdf (718.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-01-24
タイトル
タイトル Antitumor Activities of Seventeen Alkylating Agents Against Human Mammary Carcinoma (MX-1) in Nude Mice
著者 INOUE, KATSUHIRO

× INOUE, KATSUHIRO

WEKO 46830

INOUE, KATSUHIRO

Search repository
FUJIMOTO, SHUICHI

× FUJIMOTO, SHUICHI

WEKO 46831

FUJIMOTO, SHUICHI

Search repository
OGAWA, MAKOTO

× OGAWA, MAKOTO

WEKO 46832

OGAWA, MAKOTO

Search repository
キーワード
主題Scheme Other
主題 Experimental chemotherapy
キーワード
主題Scheme Other
主題 Nude mice
キーワード
主題Scheme Other
主題 Xenograft
キーワード
主題Scheme Other
主題 Human mammary carcinoma
キーワード
主題Scheme Other
主題 Antitumor alkylating agents
抄録
内容記述 The antitumor activities of seventeen antitumor alkylating agents have been studied in the xenograft of human mammary carcinoma transplanted in nude mice (MX-1). The drugs employed in this study were; cyclophosphamide, ifosfamide, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), 1-(2-chloroethyl)- 3-(4-methylcyclohexyl)-1-nitrosourea (me-CCNU), 2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy- D-glucopyranose (chlorozotocin, or DCNU), 3[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU), 1-(2-chloroethyl)-3-(methyl α-D-glucopyranos-6-yl)-1-nitrosourea (MCNU), 1-(2-chloroethyl)-3-(β-D-glucopyranosyl)-1-nitrosourea(GANU), 4-[bis(2- chloroethyl)amino]-L-phenylalanine (L-PAM), chlorambucil, busulfan, Bis(3-methylsulfonyloxypropyl)amine p-toluenesulfonate (864-T), N, N', N"-triethylenimino thiophosphoramide (thio-TEPA), carbazilquinone, dibromomannitol, procarbazine and 5-(3, 3-dimethyl-1-triazeno) imidazole-4- carboxamide (DTIC). Cyclophosphamide, ifosfamide, chlorozotocin, ACNU, MCNU, GANU, 864-T, thio-TEPA, carbazilquinone and DTIC were administered intravenously through a tail vein, and the others were given intraperitoneally. Among these seventeen antitumor alkylating agents, the most active compounds (maximum rate of tumor regression : ≧9O%) are cyclophosphamide, ACNU, L-PAM, chlorambucil, thio-TEPA, carbazilquinone and dibromomannitol. Another group of compounds showed moderate activity (maximum rate of tumor regression: 89-50%), including ifosfamide, CCNU, MCNU, GANU, busulfan, 864-T and procarbazine. The remaining three compounds showed less than moderate activity (≦49%) and were therefore considered to be inactive. These results in nude mouse-human tumor xenograft system correspond to clinically observed patterns of chemotherapy sensitivity in patients with breast cancer.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.43.3-4.89
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 43, 号 3-4, p. 89-100, 発行日 1981-03
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4334/4334.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17385
識別子タイプ HDL
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