{"created":"2021-03-01T06:22:33.079322+00:00","id":15368,"links":{},"metadata":{"_buckets":{"deposit":"de7a0e13-ad69-4083-befd-2a8a3719e153"},"_deposit":{"created_by":17,"id":"15368","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"15368"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00015368","sets":["499:508:509:1449"]},"author_link":["46830","46831","46832"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1981-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"100","bibliographicPageStart":"89","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The antitumor activities of seventeen antitumor alkylating agents have been studied in the xenograft of human mammary carcinoma transplanted in nude mice (MX-1). The drugs employed in this study were; cyclophosphamide, ifosfamide, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), 1-(2-chloroethyl)- 3-(4-methylcyclohexyl)-1-nitrosourea (me-CCNU), 2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy- D-glucopyranose (chlorozotocin, or DCNU), 3[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU), 1-(2-chloroethyl)-3-(methyl α-D-glucopyranos-6-yl)-1-nitrosourea (MCNU), 1-(2-chloroethyl)-3-(β-D-glucopyranosyl)-1-nitrosourea(GANU), 4-[bis(2- chloroethyl)amino]-L-phenylalanine (L-PAM), chlorambucil, busulfan, Bis(3-methylsulfonyloxypropyl)amine p-toluenesulfonate (864-T), N, N', N\"-triethylenimino thiophosphoramide (thio-TEPA), carbazilquinone, dibromomannitol, procarbazine and 5-(3, 3-dimethyl-1-triazeno) imidazole-4- carboxamide (DTIC). Cyclophosphamide, ifosfamide, chlorozotocin, ACNU, MCNU, GANU, 864-T, thio-TEPA, carbazilquinone and DTIC were administered intravenously through a tail vein, and the others were given intraperitoneally. Among these seventeen antitumor alkylating agents, the most active compounds (maximum rate of tumor regression : ≧9O%) are cyclophosphamide, ACNU, L-PAM, chlorambucil, thio-TEPA, carbazilquinone and dibromomannitol. Another group of compounds showed moderate activity (maximum rate of tumor regression: 89-50%), including ifosfamide, CCNU, MCNU, GANU, busulfan, 864-T and procarbazine. The remaining three compounds showed less than moderate activity (≦49%) and were therefore considered to be inactive. These results in nude mouse-human tumor xenograft system correspond to clinically observed patterns of chemotherapy sensitivity in patients with breast cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/17385"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.43.3-4.89","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4334/4334.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"INOUE, KATSUHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"46830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"FUJIMOTO, SHUICHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"46831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OGAWA, MAKOTO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"46832","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"v43n34p89_100.pdf","filesize":[{"value":"718.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v43n34p89_100.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/15368/files/v43n34p89_100.pdf"},"version_id":"6ee7d88d-3bd5-4f50-bc0e-c4dc3ff37e3a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Experimental chemotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"Nude mice","subitem_subject_scheme":"Other"},{"subitem_subject":"Xenograft","subitem_subject_scheme":"Other"},{"subitem_subject":"Human mammary carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Antitumor alkylating agents","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antitumor Activities of Seventeen Alkylating Agents Against Human Mammary Carcinoma (MX-1) in Nude Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antitumor Activities of Seventeen Alkylating Agents Against Human Mammary Carcinoma (MX-1) in Nude Mice","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1449"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-01-24"},"publish_date":"2013-01-24","publish_status":"0","recid":"15368","relation_version_is_last":true,"title":["Antitumor Activities of Seventeen Alkylating Agents Against Human Mammary Carcinoma (MX-1) in Nude Mice"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:05:08.538269+00:00"}