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Biosynthesis of Various Steroids in vitro by Isolated Adrenal Cells in Primary Aldosteronism, Cushing's Syndrome, and Adrenogenital Syndrome due to Adrenocortical Adenoma
https://doi.org/10.18999/nagjms.44.1-2.11
https://doi.org/10.18999/nagjms.44.1-2.11eee00e08-5929-4553-abb7-7847985a6eb0
名前 / ファイル | ライセンス | アクション |
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v44n12p11_22.pdf (843.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-01-24 | |||||
タイトル | ||||||
タイトル | Biosynthesis of Various Steroids in vitro by Isolated Adrenal Cells in Primary Aldosteronism, Cushing's Syndrome, and Adrenogenital Syndrome due to Adrenocortical Adenoma | |||||
言語 | en | |||||
著者 |
MIZUNO, SHIGERU
× MIZUNO, SHIGERU× FUNAHASHI, HIROOMI |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Isolated Adrenal Cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cushing's Syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Primary Aldosteronism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Virilizing Adrenal Tumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Twelve Kinds of Steroids | |||||
抄録 | ||||||
内容記述 | To a further understanding of the role of steroid hormones in adrenal disorders, we have prepared free cell system of adrenal cells, using adrenal tissues that had been removed by operation from (i) cases of Cushing's syndrome due to adrenocortical adenoma or adrenocortical hyperplasia, (ii) a case of primary aldosteronism, and (iii) a patient with virilizing adrenal tumor. Twelve important steroid hormones were measured, such as pregnenolone, cortisol and aldosterone, which were produced by these cells. Adrenal glands removed from the cases of advanced breast cancer were used for the measurement of steroids as a control. No organic lesions were confirmed in these adrenal glands. An investigation as to what characteristics the adrenal cells with various disorders show, had been carried out by examining the patterns of their steroid hormone production. The results were as follows: It was not the case that adenoma cells of each disorder produced just one of three types of steroid hormones, that is, glucocorticoids, mineralocorticoids, and androgens. In fact, it is interesting enough that each adenoma produced all steroid hormones. But, the quantitative pattern of each steroid hormone production differed characteristically from one disorder to the other. It was discovered that the symptom varies depending on the amount of the more predominantly produced hormone among these steroid hormones. Consequently, adrenal disorders can be classified into the three types before-mentioned. It seems that symptoms of these disorders were also modified by other steroid hormones being produced simultaneously. Cells of adenoma in the cases of Cushing's syndrome produced a fair amount of mineralocorticoids as well as cortisol. That is why hypokalemic alkalosis and hypertension in this disorders developed. In the case of Cushing's disease due to adrenal hyperplasia, steroid hormone production pattern was similar to that in the control. In the case of virilizing adrenal tumor, androgens were predominantly produced, with the increased production of cortisol. In fact, the latter finding was consisted with the patient's Cushingoid appearance. It was also discovered that the quantitative proportion of the various steroid hormones produced by isolated adrenal cells, varied depending on the cells which were placed on the different conditions. In the case of Cushing's syndrome due to adrenocortical adenoma, for example, the quantitative proportion of mineralocorticoids was higher where no ACTH was added to the medium, compared to that where ACTH was added. These results appear to correspond with the clinical findings of the above-mentioned disorders. And, it can be said that these data are convincing for explaining the clinical symptoms. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.44.1-2.11 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4412/4412.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 44, 号 1-2, p. 11-22, 発行日 1981-11 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/17390 | |||||
識別子タイプ | HDL |