@article{oai:nagoya.repo.nii.ac.jp:00015385, author = {MURASE, TATSURO}, issue = {1-2}, journal = {Nagoya Journal of Medical Science}, month = {Nov}, note = {Using sixty-four cases of bladder cancer, the distribution of carcinomatous lesions, carcinoma in situ, and atypism were observed by step section of the entire urothelium. Carcinoma of the bladder was divided into four tumor types in accordance with the mapping of the disease foci, the patterns of tumor growth, and the DNA distribution pattern in the tumor cells. Type 1 was localized consisting mainly of papillary non-invastive tumors. Atypia was mild around the tumor, and neither atypia nor carcinoma in situ was seen in sites distant from the tumors. Type 2 was multifocal, non-invasive, and consisted mainly of papillary tumors. Type 3 was multifocal, invasive and multiple carcinomata in situ were present at sites distant from the tumors. Type 4 was localized and invasive with no findings suggestive of precancerous lesions in the bladder mucosa. Type 4 tumors grew very rapidly and were highly malignant. According to the retrospective analysis of the clinical course of each type, a plan for reasonable treatment of the bladder cancer was proposed as follows. Type 1; This type of tumor may be controlled sufficiently by transurethral resection. In cases of T2 (B1) or more, dissection of the lymph node is necessary. Type 2; This type may basically be controlled by transurethral resection, but careful follow-up is required because of high incidence of recurrence. When T2 (B1) or more are diagnosed, total cystectomy is indicated. Type 3; Total cystectomy including the urethra and dissections of the lymph node are necessary. Type 4; Partial, sometimes total, cystectomy and dissection of the regional lymph node at an early stage are necessary.}, pages = {1--15}, title = {Pathologial Study of Bladder Cancer by Mappling of Urothelium}, volume = {45}, year = {1982} }