@article{oai:nagoya.repo.nii.ac.jp:00015466, author = {NAMBA, YOSHIMICHI and SUZUKI, ASAKATSU and TAKESHIMA, NOBORU and KATO, NOBUO}, issue = {3-4}, journal = {Nagoya Journal of Medical Science}, month = {Mar}, note = {Bactericidal activities of six commonly used disinfectants against seven different species of clinically isolatcd bacteria, mainly glucose-nonfermentative Gram-negative bacilli, were compared. In terms of mean values of the minimum bactericidal concentration (MBC), benzethonium chloride showed the highest efficacy, followed in order by chlorhexidine gluconate, alkyldiaminoethylglycine hydrochloride, glutaraldehyde, povidone-iodine, and phenol. However, mean MBCs of benzethonium chloride, alkyldiaminoethylglycine hydrochloride and chlorhexidine gluconate against individual species covered a far wider range from species to species compared with those of the other three disinfectants. In addition, bactericidal activities of the above-mentioned three disinfectants against Pseudomonas cepacia and Achromobacter xylosoxidans ranged more widely from strain to strain than against other species. When the minimum concentrations of individual disinfectants recommended for hospital use by the manufacturers were used, chlorhexidine gluconate (0.02%), alkyldiaminoethylglycine hydrochloride (0.1%), benzethonium chloride (0.1%) and povidone-iodine (0.75%) were not bactericidal to definite numhers of bacterial strains tested. Among them, chlorhexidine gluconate at the concentration recommended was ineffective against many strains of all bacterial species tested, especially against strains of glucose-nonfermentative Gram-negative bacilli except for Pseudomonas aerugillosa. Alkyldiaminoethylglycine hydrochloride was also remarkably ineffective against Staphylococcus aureus and P. cepacia. Among all the species tested, P. cepacia showed the strongest resistance to the disinfectants tested at the minimum concentrations of individual disinfectants recommended for hospital use by the manufacturers.}, pages = {101--112}, title = {Comparative Study of Bactericidal Activities of Six Different Disinfectants}, volume = {47}, year = {1985} }