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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 48(1-4)

The Influence of Portal Vein Occlusion on Liver Mitochondria in Rats after Releasing Biliary Obstruction

https://doi.org/10.18999/nagjms.48.1-4.11
https://doi.org/10.18999/nagjms.48.1-4.11
aed8d619-bd66-4c18-8755-6810c6801e0c
名前 / ファイル ライセンス アクション
v48n14p11_20.pdf v48n14p11_20.pdf (1.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-02-13
タイトル
タイトル The Influence of Portal Vein Occlusion on Liver Mitochondria in Rats after Releasing Biliary Obstruction
著者 IWASE, MASANORI

× IWASE, MASANORI

WEKO 47134

IWASE, MASANORI

Search repository
キーワード
主題Scheme Other
主題 occlusion of the portal vein
キーワード
主題Scheme Other
主題 liver mitochondria
キーワード
主題Scheme Other
主題 respiratory function
キーワード
主題Scheme Other
主題 obstructive jaundice
キーワード
主題Scheme Other
主題 bile drainage
抄録
内容記述 Biliary obstruction often follows advanced cancers of the biliary system, such as pancreas cancer, which requires a resection of the involved portion of the portal vein. To improve the patient's state of obstructive jaundice, bile drainage should be performed before the operation. Temporary occlusion of the portal vein is inevitable for a resection and reconstruction of the portal vein, and its detrimental influence on the liver remains to be resolved. In this study, the effect of portal vein occlusion on rat liver mitochondria was investigated after releasing biliary obstruction. The common bile duct of the male Donryu rat was ligated and, after a certain duration, was recanalized to allow for external bile drainage. Then the portal blood flow was blocked for either 15 or 30-min. At the end of the experiment, the following parameters were examined: the respiratory functions and ultrastructures of liver mitochondria, and the serum levels of hepatic enzymes. A significant reduction of the respiratory functions was observed in the 30-min occlusion group regardless of the length of the biliary obstruction period; also the ultrastructures of the liver mitochondria showed severe changes associated with increased s-GPT and m-GOT. These results indicate that 15-min occlusion of the portal vein after releasing biliary obstruction has a negligible effect on the liver functions, but 30-min occlusion induces dysfunction of liver cells. Therefore, additional countermeasures to clear such liver dysfunction should be employed in biliary tract surgery, provided that a prolonged portal vein occlusion is inevitable.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.48.1-4.11
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 48, 号 1-4, p. 11-20, 発行日 1986-03
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4814/4814.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17487
識別子タイプ HDL
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