{"created":"2021-03-01T06:22:40.063273+00:00","id":15477,"links":{},"metadata":{"_buckets":{"deposit":"23aa60b4-e350-40ea-93e2-96951b1937f2"},"_deposit":{"created_by":17,"id":"15477","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"15477"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00015477","sets":["499:508:509:1460"]},"author_link":["47163","47164","47165","47166"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"30","bibliographicPageStart":"21","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have developed a new method to quantify the mucociliary transport force (MCTF). We validated the method by examining the effects of isoproterenol (Iso), norepinephrine (NE), epinephrine (Epi), and acetylcholine (ACh) on MCTF. In the first series of experiments, the effects of leukotrienes (LTs) on MCTF were investigated. In accordance with previous studies, Iso, NE, and ACh induced increases in MCTF, but Epi did not cause any significant effects. In the second series of experiments, LTC4 induced a significant increase in MCTF and LTD4 induced a significant decrease in MCTF, although these effects were transient. Neither LTB4 nor LTE4 affected MCTF. The effects of LTC4 and LTD4 were inhibited by a LT antagonist, FPL55712. These results indicate that we have developed a useful and sensitive method for quantitative determination of the immediate and direct effect of agonists on mucociliary transport, and that selective agonists may be involved in the defense mechanism of the lung to carry mucus plugs or locally produced debris out of the airways.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/17495"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.49.1-4.21","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4914/4914.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YAMAKI, KENICHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47163","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NODA, YASUNOBU","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAKAGI, KENZO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47165","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SATAKE, TATSUO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47166","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"v49n14p21_30.pdf","filesize":[{"value":"559.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v49n14p21_30.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/15477/files/v49n14p21_30.pdf"},"version_id":"a5a26d0b-5531-42b3-a280-daf716c01766"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"mucociliary transport force","subitem_subject_scheme":"Other"},{"subitem_subject":"isoproterenol","subitem_subject_scheme":"Other"},{"subitem_subject":"acetylcholine","subitem_subject_scheme":"Other"},{"subitem_subject":"frog palate","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Adrenergic and Cholinergic Agents and Leukotrienes on Mucociliary Transport Force Measured by Using Frog Palate","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Adrenergic and Cholinergic Agents and Leukotrienes on Mucociliary Transport Force Measured by Using Frog Palate","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1460"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-02-13"},"publish_date":"2013-02-13","publish_status":"0","recid":"15477","relation_version_is_last":true,"title":["Effects of Adrenergic and Cholinergic Agents and Leukotrienes on Mucociliary Transport Force Measured by Using Frog Palate"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T05:50:06.251534+00:00"}