{"created":"2021-03-01T06:22:40.509145+00:00","id":15484,"links":{},"metadata":{"_buckets":{"deposit":"f47e4fcb-4df7-4345-ba2e-093fc696aeb0"},"_deposit":{"created_by":17,"id":"15484","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"15484"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00015484","sets":["499:508:509:1461"]},"author_link":["47193","47194","47195","47196","47197","47198"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"26","bibliographicPageStart":"17","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Forty-two patients with neoplastic diseases received intravenous administration of PPD (PPD-V), and tumor markers were monitored between January, 1986 and February, 1987. Tumor markers such as CEA, AFP, SCC, CA125, IAP and polyamines decreased significantly following the PPD-V therapy. In some cases, PPD-V therapy also reduced the progression of clinical manifestation of the disease. We could not detect serum IL-2 or TNF activity. IL-2 production and sensitivity of lymphocytes were also undetectable. Intravenous administration of PPD was concluded to be effective as an adjuvant therapy against human neoplastic disease. A reduction of tumor markers was observed in 19 of the 26 assessable patients (73%). We discussed the mechanism of suppression of tumor markers by PPD-V therapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/17502"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.50.1-4.17","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5014/5014.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IINUMA, MASAO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KATO, KATSUYA","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47194","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"AOKI, HIIZU","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ANDO, KOICHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAKASHIMA, IZUMI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YOSHII, SAIJI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47198","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"v50n14p17_26.pdf","filesize":[{"value":"703.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v50n14p17_26.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/15484/files/v50n14p17_26.pdf"},"version_id":"60bc2e11-62ec-48a7-a0b5-1822af53bc13"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"BRM","subitem_subject_scheme":"Other"},{"subitem_subject":"PPD-V","subitem_subject_scheme":"Other"},{"subitem_subject":"suppression of tumor markers","subitem_subject_scheme":"Other"},{"subitem_subject":"adjuvant immunotherapy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Purified Protein Derivative (PPD) Tuberculin as a Biological Response Modifier: I. Suppression of Tumor Markers by Intravenous Administration of PPD","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Purified Protein Derivative (PPD) Tuberculin as a Biological Response Modifier: I. Suppression of Tumor Markers by Intravenous Administration of PPD","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1461"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-02-13"},"publish_date":"2013-02-13","publish_status":"0","recid":"15484","relation_version_is_last":true,"title":["Purified Protein Derivative (PPD) Tuberculin as a Biological Response Modifier: I. Suppression of Tumor Markers by Intravenous Administration of PPD"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T05:50:24.108687+00:00"}