{"created":"2021-03-01T06:22:40.835280+00:00","id":15489,"links":{},"metadata":{"_buckets":{"deposit":"0c7e5730-1af7-4f12-aa24-f15b6f56d407"},"_deposit":{"created_by":17,"id":"15489","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"15489"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00015489","sets":["499:508:509:1462"]},"author_link":["47223","47224","47225","47226","47227","47228","47229"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"23","bibliographicPageStart":"17","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Isolated adipocytes from severely diabetic rats exhibited hypersensitivity to epinephrine at low concentrations (0.05-0.1μM) on lipolysis, compared with isolated adipocytes from normal and mildly diabetic rats. Hypersensitivity to dibutyryl cyclic AMP and theophylline at concentrations from 0.05 to 0.50mM was not observed in adipocytes of severely diabetic rats. Insulin could not exert an inhibitory effect on epinephrineinduced lipolysis in adipocytes of severely diabetic rats. In isolated adipocytes from normal rats, hyperosmolarity due to the combination of 50mM glucose and 100 mM sodium chloride only had an inhibitory effect on 0.25μM epinephrine-induced lipolysis. Ten mM β-hydroxybutyrate did not inhibit lipolysis caused by epinephrine although any lipolysis stimulated by epinephrine, dibutyryl cyclic AMP and theophylline was inhibited by insulin. Our present findings may partly explain insulin resistance in the severely diabetic state and the pathogenesis of the absence of ketosis in hyperglycemic hyperosmolar conditions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/17507"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.51.1-4.17","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5114/5114.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KAMEI, IZUMI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47223","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HOTTA, NIGISHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47224","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAKUTA, HIRONOBU","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47225","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KIMURA, MASAO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47226","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"FUKASAWA, HIDEO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47227","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KOH, NAOKI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47228","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SAKAMOTO, NOBUO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47229","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"v51n14p17_23.pdf","filesize":[{"value":"547.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"v51n14p17_23.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/15489/files/v51n14p17_23.pdf"},"version_id":"6184b1e4-a1f4-4f84-871b-97bd64c31c91"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"β-Hydroxybutyrate","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyperosmolarity","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin","subitem_subject_scheme":"Other"},{"subitem_subject":"Isolated adipocytes","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipolytic and antilipolytic agents","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Lipolytic and Antilipolytic Agents on Glycerol and Free Fatty Acid Release from Isolated Adipocytes of Normal and Diabetic Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Lipolytic and Antilipolytic Agents on Glycerol and Free Fatty Acid Release from Isolated Adipocytes of Normal and Diabetic Rats","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-02-13"},"publish_date":"2013-02-13","publish_status":"0","recid":"15489","relation_version_is_last":true,"title":["Effects of Lipolytic and Antilipolytic Agents on Glycerol and Free Fatty Acid Release from Isolated Adipocytes of Normal and Diabetic Rats"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T05:50:37.551389+00:00"}